Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 11/20 | 1.00 |
| ▸ | DYRK1B | Q9Y463 | 4/20 | 1.00 |
| ▸ | SNCA | P37840 | 2/20 | 0.74 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.70 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.67 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.67 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.59 |
| ▸ | RELA | Q04206 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11724806 | 0.91 | DYRK1A (1.00) | DYRK1ADYRK1BSNCAHSD17B10HSD17B1 | |
| SCHEMBL22881 | 0.84 | DYRK1A (0.73) | DYRK1ADYRK1BSNCAHSD17B10HSD17B1 | |
| SCHEMBL27093077 | 0.81 | DYRK1A (0.67) | DYRK1ADYRK1BHSD17B10MEN1MAPT | |
| SCHEMBL11728977 | 0.80 | NPC1 (0.73) | DYRK1ADYRK1BSNCAHSD17B10MEN1 | |
| SCHEMBL22880 | 0.80 | DYRK1A (0.67) | DYRK1ADYRK1BSNCAHSD17B10HSD17B1 | |
| SCHEMBL31035 | 0.80 | HSD17B1 (1.00) | DYRK1ADYRK1BSNCAHSD17B1HSD17B2 | |
| SCHEMBL544349 | 0.79 | DYRK1A (0.75) | DYRK1ADYRK1BHSD17B10HSD17B1HSD17B2 | |
| SCHEMBL11731028 | 0.79 | RAB9A (0.71) | DYRK1ADYRK1BSNCAHSD17B10HSD17B1 | |
| SCHEMBL11730371 | 0.79 | RAB9A (0.72) | DYRK1ADYRK1BSNCAHSD17B10HSD17B1 | |
| SCHEMBL23256883 | 0.78 | DYRK1A (0.66) | DYRK1ADYRK1BSNCAHSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609089-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2013-07-03 | — | — | EP | claimed |
| WO-2012025638-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2012-03-01 | — | — | WO | claimed |
| EP-2609089-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012025638-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2012-03-01 | — | — | WO | disclosed |
| WO-2012025638-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2012-03-01 | — | — | WO | disclosed |