Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 10/20 | 0.67 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.67 |
| ▸ | HSD17B1 | P14061 | 6/20 | 0.61 |
| ▸ | HSD17B2 | P37059 | 5/20 | 0.61 |
| ▸ | SNCA | P37840 | 2/20 | 0.59 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22905 | 0.80 | DYRK1A (1.00) | DYRK1ADYRK1BHSD17B1HSD17B2SNCA | |
| SCHEMBL23714 | 0.80 | RAB9A (0.64) | DYRK1A | |
| SCHEMBL5442274 | 0.77 | NPC1 (0.66) | DYRK1A | |
| SCHEMBL11724806 | 0.76 | DYRK1A (1.00) | DYRK1ADYRK1BHSD17B1HSD17B2SNCA | |
| SCHEMBL31035 | 0.76 | HSD17B1 (1.00) | DYRK1ADYRK1BHSD17B1HSD17B2SNCA | |
| SCHEMBL544349 | 0.75 | DYRK1A (0.75) | DYRK1ADYRK1BHSD17B1HSD17B2DYRK2 | |
| SCHEMBL10170616 | 0.74 | DYRK1A (1.00) | DYRK1ADYRK1BHSD17B1HSD17B2 | |
| SCHEMBL27717411 | 0.74 | DYRK1A (0.73) | DYRK1ADYRK1BHSD17B1HSD17B2DYRK2 | |
| SCHEMBL544933 | 0.73 | DYRK1A (0.65) | DYRK1ADYRK1BHSD17B1HSD17B2SNCA | |
| SCHEMBL11730371 | 0.72 | RAB9A (0.72) | DYRK1ADYRK1BHSD17B1HSD17B2SNCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609089-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2013-07-03 | — | — | EP | claimed |
| WO-2012025638-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2012-03-01 | — | — | WO | claimed |
| EP-2609089-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012025638-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2012-03-01 | — | — | WO | disclosed |