Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WIZ | O95785 | 6/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 4/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 5/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | IKZF2 | Q9UKS7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22906655 | 0.85 | ITGB3 (0.41) | WIZMAOACRBNITGB3ITGA2B | |
| SCHEMBL20120388 | 0.82 | CRBN (0.59) | WIZCRBNIKZF2 | |
| SCHEMBL22907149 | 0.80 | CRBN (0.48) | WIZCRBNIKZF2 | |
| SCHEMBL22906707 | 0.79 | MAOA (0.36) | MAOACRBNITGB3ITGA2BHRH3 | |
| SCHEMBL24291214 | 0.76 | CRBN (0.61) | WIZCRBNIKZF2 | |
| SCHEMBL20046456 | 0.71 | CRBN (0.62) | WIZCRBNIKZF2 | |
| SCHEMBL20231099 | 0.71 | CRBN (0.62) | WIZCRBNIKZF2 | |
| SCHEMBL24501067 | 0.70 | CRBN (0.64) | WIZCRBNITGB3ITGA2BIKZF2 | |
| SCHEMBL24817722 | 0.70 | CRBN (0.61) | WIZCRBNIKZF2 | |
| SCHEMBL29439985 | 0.70 | CRBN (0.64) | WIZCRBNITGB3ITGA2BIKZF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021011913-A1 | TAU-PROTEIN TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2021-01-21 | — | — | WO | disclosed |