SCHEMBL22908415

SCHEMBL22908415

Cc1cc(-c2ccc(F)cn2)cc(Cl)c1C1C(=O)CC2(CCN(C(=O)C3CC3)CC2)CC1=O

nearest known ligand 0.36

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.36
PARP1 P09874 3/20 0.35
PARP2 Q9UGN5 3/20 0.35
MGLL Q99685 2/20 0.34
PIK3CD O00329 1/20 0.34
P2RX7 Q99572 2/20 0.34
ABL1 P00519 1/20 0.34
ALOX5AP P20292 1/20 0.34
FEN1 P39748 1/20 0.34
BACE1 P56817 1/20 0.34
BACE2 Q9Y5Z0 1/20 0.34
RORC P51449 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22908412 0.87 P2RX7 (0.36) PIK3CDP2RX7
SCHEMBL21361225 0.85 ABCG2 (0.37) ALDH1A1
SCHEMBL24120132 0.85 ABL1 (0.36) ALDH1A1ABL1RORC
SCHEMBL21361241 0.82 ALDH1A1 (0.37) ALDH1A1MGLLPIK3CDRORC
SCHEMBL21361254 0.81 RORC (0.40) ALDH1A1RORC
SCHEMBL21361291 0.81 FASN (0.37) PIK3CDABL1
SCHEMBL24120341 0.80 CHRM4 (0.37) ABL1
SCHEMBL22908414 0.79 CYP1A2 (0.41) P2RX7BACE1
SCHEMBL22908404 0.78 CHEK1 (0.36) ALDH1A1P2RX7
SCHEMBL22941887 0.78 ABL1 (0.39) ABL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021009048-A1 HERBICIDAL CYCLOHEXANEDIONE DERIVATIVES SYNGENTA CROP PROTECTION AG (CH) 2021-01-21 WO disclosed