SCHEMBL22908423

SCHEMBL22908423

CC#Cc1cc(Cl)c(C2C(=O)CC3(CCN(C(=O)C(F)F)CC3)CC2=O)c(OC)c1

nearest known ligand 0.32

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
BTK Q06187 1/20 0.31
KDM4E B2RXH2 1/20 0.31
MEN1 O00255 1/20 0.31
MAPT P10636 1/20 0.31
KMT2A Q03164 1/20 0.31
ADAM17 P78536 1/20 0.30
ADAMTS5 Q9UNA0 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22908429 0.92
SCHEMBL24120402 0.91
SCHEMBL21285034 0.90 GRM5 (0.31)
SCHEMBL22908536 0.89 CYP2D6 (0.37) BTKMEN1MAPTKMT2A
SCHEMBL22908407 0.87 MEN1 (0.30) KDM4EMEN1MAPTKMT2A
SCHEMBL22908541 0.86 LMNA (0.38) MEN1KMT2A
SCHEMBL22908427 0.86 HTR4 (0.34) BTK
SCHEMBL22908447 0.86 HTR4 (0.34) BTK
SCHEMBL22908540 0.85 CYP2D6 (0.41) MEN1KMT2A
SCHEMBL22908425 0.84 CCR1 (0.32) ADAMTS5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021009048-A1 HERBICIDAL CYCLOHEXANEDIONE DERIVATIVES SYNGENTA CROP PROTECTION AG (CH) 2021-01-21 WO disclosed