SCHEMBL22908425

SCHEMBL22908425

CC#Cc1cc(Cl)c(C2C(=O)CC3(CCN(C(=O)CC(C)(F)F)CC3)CC2=O)c(OC)c1

nearest known ligand 0.32

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CCR1 P32246 8/20 0.32
GHSR Q92847 2/20 0.32
USP2 O75604 3/20 0.31
ACACA Q13085 1/20 0.31
ALDH1A1 P00352 1/20 0.31
ADAMTS5 Q9UNA0 1/20 0.31
CYP2C19 P33261 3/20 0.31
CYP3A4 P08684 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP2C9 P11712 1/20 0.31
GAA P10253 1/20 0.30
KCNH2 Q12809 1/20 0.30
TSHR P16473 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22908540 0.88 CYP2D6 (0.41) USP2ALDH1A1CYP2C19CYP3A4CYP1A2
SCHEMBL22908427 0.87 HTR4 (0.34) ACACAALDH1A1CYP3A4
SCHEMBL22908424 0.86 JAK1 (0.35) GHSRADAMTS5KCNH2
SCHEMBL22908536 0.85 CYP2D6 (0.37) CYP1A2CYP2C9TSHR
SCHEMBL29391841 0.85 GPR183 (0.40) ACACAALDH1A1
SCHEMBL22908534 0.84 HTR1A (0.34) ACACAALDH1A1SMN1; SMN2
SCHEMBL22908423 0.84 BTK (0.31) ADAMTS5
SCHEMBL22908435 0.84 GHSR (0.33) GHSRALDH1A1ADAMTS5CYP2C19CYP3A4
SCHEMBL22908447 0.83 HTR4 (0.34) ACACAKCNH2
SCHEMBL22908541 0.83 LMNA (0.38) ALDH1A1GAATSHRSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021009048-A1 HERBICIDAL CYCLOHEXANEDIONE DERIVATIVES SYNGENTA CROP PROTECTION AG (CH) 2021-01-21 WO disclosed