SCHEMBL22908535

SCHEMBL22908535

CC#Cc1cc(Cl)c(C2C(=O)CC3(CCN(C(=O)NC(=O)C(C)(C)C)CC3)CC2=O)c(OC)c1

nearest known ligand 0.32

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.32
KCNT1 Q5JUK3 1/20 0.31
ACACA Q13085 2/20 0.31
NPY2R P49146 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24120403 0.91
SCHEMBL21344249 0.90 GRM5 (0.31) ACACA
SCHEMBL22908534 0.90 HTR1A (0.34) POLBKCNT1ACACA
SCHEMBL22908427 0.88 HTR4 (0.34) ACACA
SCHEMBL22908536 0.85 CYP2D6 (0.37)
SCHEMBL29391841 0.85 GPR183 (0.40) ACACA
SCHEMBL21343875 0.85
SCHEMBL22908447 0.83 HTR4 (0.34) ACACA
SCHEMBL22908541 0.83 LMNA (0.38)
SCHEMBL22908425 0.83 CCR1 (0.32) ACACA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021009048-A1 HERBICIDAL CYCLOHEXANEDIONE DERIVATIVES SYNGENTA CROP PROTECTION AG (CH) 2021-01-21 WO disclosed