Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 3/20 | 0.39 |
| ▸ | NOS1 | P29475 | 3/20 | 0.39 |
| ▸ | NOS2 | P35228 | 3/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.35 |
| ▸ | TAS1R3 | Q7RTX0 | 4/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22909904 | 0.92 | REN (0.41) | RENAAK1KEAP1NFE2L2CTSL | |
| SCHEMBL21411582 | 0.92 | REN (0.41) | RENAAK1KEAP1NFE2L2CTSL | |
| SCHEMBL21411585 | 0.92 | REN (0.41) | RENAAK1KEAP1NFE2L2CTSL | |
| SCHEMBL21431089 | 0.81 | KEAP1 (0.50) | KEAP1NFE2L2CTSLCTSSCTSK | |
| SCHEMBL21411560 | 0.81 | KEAP1 (0.50) | KEAP1NFE2L2CTSLCTSSCTSK | |
| SCHEMBL21411564 | 0.81 | KEAP1 (0.50) | KEAP1NFE2L2CTSLCTSSCTSK | |
| SCHEMBL21411566 | 0.77 | PTPN1 (0.39) | KEAP1NFE2L2MMP2MMP9MMP8 | |
| SCHEMBL21411567 | 0.77 | PTPN1 (0.39) | KEAP1NFE2L2MMP2MMP9MMP8 | |
| SCHEMBL13030665 | 0.75 | AAK1 (0.48) | RENAAK1CTSLCTSSCTSK | |
| SCHEMBL21411586 | 0.75 | KEAP1 (0.40) | AAK1KEAP1NFE2L2CTSLCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11339193-B2 | CDP protein secretion inhibitors | KEZAR LIFE SCIENCES (US) | 2022-05-24 | — | — | US | disclosed |
| US-20210017233-A1 | CDP PROTEIN SECRETION INHIBITORS | ENODIA THERAPEUTICS SAS (FR) | 2021-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11339193-B2 | CDP protein secretion inhibitors | SEC61G, SEC61A1, SEC61B | REN 4067/4885NOS3 4106/4885NOS1 3972/4885 |
| US-20210017233-A1 | CDP PROTEIN SECRETION INHIBITORS | SEC61G, SEC61A1, SEC61B | REN 4067/4885NOS3 4106/4885NOS1 3972/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.