Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26A1 | O43174 | 4/20 | 0.76 |
| ▸ | CYP27A1 | Q02318 | 2/20 | 0.74 |
| ▸ | MIF | P14174 | 9/20 | 0.73 |
| ▸ | CYP24A1 | Q07973 | 4/20 | 0.72 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.63 |
| ▸ | NPC1 | O15118 | 3/20 | 0.62 |
| ▸ | RAB9A | P51151 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.60 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.60 |
| ▸ | RELA | Q04206 | 1/20 | 0.60 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL229133 | 1.00 | CYP26A1 (0.76) | CYP26A1CYP27A1MIFCYP24A1ABCB1 | |
| SCHEMBL16210587 | 0.85 | CYP26A1 (0.76) | CYP26A1CYP27A1MIFCYP24A1ABCB1 | |
| SCHEMBL16210588 | 0.85 | CYP26A1 (0.76) | CYP26A1CYP27A1MIFCYP24A1ABCB1 | |
| SCHEMBL8169114 | 0.82 | MIF (1.00) | CYP26A1CYP27A1MIFCYP24A1ABCB1 | |
| SCHEMBL8169116 | 0.82 | MIF (1.00) | CYP26A1CYP27A1MIFCYP24A1ABCB1 | |
| SCHEMBL9619490 | 0.81 | NFE2L2 (0.71) | CYP26A1CYP27A1MIFCYP24A1ABCB1 | |
| SCHEMBL9619624 | 0.81 | ALDH1A1 (0.79) | CYP26A1CYP27A1MIFCYP24A1ABCB1 | |
| SCHEMBL28096059 | 0.80 | CYP26A1 (0.67) | CYP26A1CYP27A1MIFCYP24A1ABCB1 | |
| SCHEMBL6958968 | 0.79 | MIF (0.85) | CYP26A1CYP27A1MIFABCB1NPC1 | |
| SCHEMBL12760787 | 0.78 | MIF (0.67) | CYP26A1CYP27A1MIFCYP24A1ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8399520-B2 | Selective estrogen receptor modulator | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2013-03-19 | — | — | US | disclosed |
| US-20120004315-A1 | Selective Estrogen Receptor Modulator | RADIUS HEALTH, INC. | 2012-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120004315-A1 | Selective Estrogen Receptor Modulator | ESR1, GPER1, ESR2 | CYP26A1 440/4885CYP27A1 1688/4885MIF 2451/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.