Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.61 |
| ▸ | TSHR | P16473 | 4/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.54 |
| ▸ | USP2 | O75604 | 7/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.54 |
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22914762 | 0.93 | CYP2D6 (0.58) | ALDH1A1CYP2C19MAPK1CYP2D6CYP2C9 | |
| SCHEMBL22914839 | 0.88 | CYP3A4 (0.55) | ALDH1A1CYP2C19MAPK1CYP2D6CYP2C9 | |
| SCHEMBL22914750 | 0.87 | CYP2D6 (0.50) | ALDH1A1CYP2C19MAPK1CYP2D6CYP2C9 | |
| SCHEMBL22914827 | 0.82 | EGLN2 (0.52) | ALDH1A1CYP2C19MAPK1CYP2D6CYP2C9 | |
| SCHEMBL6755665 | 0.82 | CASP6 (0.63) | ALDH1A1CYP2C19CYP2D6CYP2C9CYP1A2 | |
| SCHEMBL22914764 | 0.81 | CYP2C9 (0.57) | ALDH1A1CYP2C19MAPK1CYP2D6CYP2C9 | |
| SCHEMBL22914849 | 0.81 | ALDH1A1 (0.60) | ALDH1A1CYP2C19MAPK1CYP2D6CYP2C9 | |
| SCHEMBL18357677 | 0.79 | EGLN2 (0.54) | ALDH1A1CYP2C19MAPK1CYP2D6CYP2C9 | |
| SCHEMBL22922220 | 0.78 | KCNH2 (0.60) | ALDH1A1CYP2C19MAPK1CYP2D6CYP2C9 | |
| SCHEMBL22914793 | 0.78 | ALDH1A1 (0.68) | ALDH1A1CYP2C19MAPK1CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230022770-A1 | NOVEL PYRIDAZINES | BOEHRINGER INGELHEIM INT (DE) | 2023-01-26 | — | — | US | disclosed |
| US-20210024495-A1 | NOVEL PYRIDAZINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-01-28 | — | — | US | disclosed |
| US-20210024492-A1 | NOVEL PYRIDAZINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-01-28 | — | — | US | disclosed |
| WO-2021013832-A1 | 1-(6-(METHOXY)PYRIDAZIN-3-YL)CYCLOPROPANE-1-CARBOXAMIDE DERIVATIVES AS AUTOTAXIN (ATX) MODULATORS FOR THE TREATMENT OF INFLAMMATORY AIRWAY DISEASES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-01-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210024492-A1 | NOVEL PYRIDAZINES | ENPP2, PLPBP, PRDX6 | ALDH1A1 4630/4885CYP2C19 4349/4885MAPK1 3592/4885 |
| US-20210024495-A1 | NOVEL PYRIDAZINES | ENPP2, PLPBP, PRDX6 | ALDH1A1 4630/4885CYP2C19 4349/4885MAPK1 3592/4885 |
| US-20230022770-A1 | NOVEL PYRIDAZINES | ENPP2, PLPBP, PRDX6 | ALDH1A1 4630/4885CYP2C19 4349/4885MAPK1 3592/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.