Sugi Predict

Sugi Predict / Compounds / SCHEMBL229154

SCHEMBL229154

SCHEMBL229154

O=[N+]([O-])c1ccc(O)cc1Br

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ BACE1 P56817 2/20 0.49
▸ EGFR P00533 1/20 0.47
▸ GPR35 Q9HC97 3/20 0.47
▸ CYP19A1 P11511 1/20 0.46
▸ AAK1 Q2M2I8 1/20 0.45
▸ NPSR1 Q6W5P4 1/20 0.44
▸ RXFP1 Q9HBX9 1/20 0.44
▸ ALDH1A1 P00352 4/20 0.44
▸ TSHR P16473 3/20 0.44
▸ ALOX15 P16050 1/20 0.44
▸ CA12 O43570 1/20 0.43
▸ CA1 P00915 1/20 0.43
▸ CA2 P00918 1/20 0.43
▸ CA9 Q16790 1/20 0.43
▸ ESR1 P03372 1/20 0.42
▸ ESR2 Q92731 1/20 0.42
▸ TP53 P04637 2/20 0.42
▸ HPGD P15428 2/20 0.42
▸ SMN1; SMN2 Q16637 2/20 0.42
▸ MAPK1 P28482 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29766271 1.00 BACE1 (0.49) BACE1EGFRGPR35CYP19A1AAK1
SCHEMBL228469 0.83 ALDH1A1 (0.54) BACE1EGFRGPR35ALDH1A1TSHR
SCHEMBL29577003 0.80 TSHR (0.56) BACE1EGFRGPR35NPSR1RXFP1
SCHEMBL213758 0.80 TSHR (0.56) BACE1EGFRGPR35NPSR1RXFP1
SCHEMBL29431838 0.78 CYP19A1 (0.49) GPR35CYP19A1AAK1ALDH1A1TSHR
SCHEMBL68980 0.78 GPR35 (0.67) BACE1EGFRGPR35NPSR1RXFP1
SCHEMBL165733 0.78 CYP19A1 (0.49) GPR35CYP19A1AAK1ALDH1A1TSHR
SCHEMBL29479746 0.78 GPR35 (0.67) BACE1EGFRGPR35NPSR1RXFP1
Methane SCHEMBL27823028 0.78 TSHR (0.54) BACE1EGFRGPR35NPSR1RXFP1
SCHEMBL9197991 0.78 AAK1 (0.60) GPR35CYP19A1AAK1ALDH1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 221 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220372008-A1 LUCIFERIN DERIVATIVES AND A METHOD FOR SYNTHESIS THEREOF VIDYASIRIMEDHI INSTITUTE OF SCIENCE AND TECHNOLOGY (TH) 2022-11-24 — — US claimed
CN-109776498-B Preparation method of cilostazol 浙江永宁药业股份有限公司 2020-04-07 — — CN claimed
CN-109776498-A A kind of preparation method of Cilostazol 浙江永宁药业股份有限公司 2019-05-21 — — CN claimed
EP-3820850-B1 PHENYL/PYRIDYL-N-PHENYL/PYRIDYL DERIVATIVES FOR TREATING A RNA VIRUS INFECTION ABIVAX (FR) 2026-04-01 — — EP disclosed
CN-121652078-A Synthesis method of 3-bromo-4-nitrophenol 苏州汉德创宏生化科技有限公司 2026-03-13 — — CN disclosed
CN-121652078-A Synthesis method of 3-bromo-4-nitrophenol 苏州汉德创宏生化科技有限公司 2026-03-13 — — CN disclosed
US-20260035348-A1 PHENYL-N-QUINOLINE DERIVATIVES FOR TREATING A RNA VIRUS INFECTION ABIVAX (FR) 2026-02-05 — — US disclosed
US-20250361237-A1 1,4-DIHYDROBENZO[D]PYRAZOLO[3,4-F][1,3]DIAZEPINE DERIVATIVES AND RELATED COMPOUNDS AS LRRK2, NUAK1 AND/OR TYK2 KINASE MODULATORS FOR THE TREATMENT OF E.G. AUTOIMMUNE DISEASE ORIGENIS GMBH (DE) 2025-11-27 — — US disclosed
US-12479802-B2 Phenyl-n-quinoline derivatives for treating a RNA virus infection ABIVAX (FR) 2025-11-25 — — US disclosed
US-12421206-B2 Aryl-n-aryl derivatives for treating a RNA virus infection ABIVAX (FR) 2025-09-23 — — US disclosed
US-12384788-B2 1,4-dihydrobenzo[d]pyrazolo[3,4-f][1,3]diazepine derivatives and related compounds as LRRK2, NUAK1 and/or TYK2 kinase modulators for the treatment of e.g. autoimmune disease ORIGENIS GMBH (DE) 2025-08-12 — — US disclosed
EP-1294378-A4 THROMBOPOIETIN MIMETICS SMITHKLINE BEECHAM CORP (US) 2004-01-28 — — EP disclosed
EP-1377580-A2 BENZENESULFONIC ACID INDOL-5-YL ESTERS AS ANTAGONISTS OF THE 5-HT6 RECEPTOR ELI LILLY AND COMPANY (US) 2004-01-07 — — EP disclosed
CN-1444477-A Thrombopoietin mimetics SMITHKLINE BEECHAM CORP (US) 2003-09-24 — — CN disclosed
EP-1294378-A2 THROMBOPOIETIN MIMETICS SMITHKLINE BEECHAM CORPORATION (US) 2003-03-26 — — EP disclosed
WO-2002060871-A2 BENZENESULFONIC ACID INDOL-5-YL ESTERS AS ANTAGONISTS OF THE 5-HT6 RECEPTOR ELI LILLY AND COMPANY (US) 2002-08-08 — — WO disclosed
CN-1076341-C Selective nitration of phenol derivatives JUNSEI CHEMICAL (JP) 2001-12-19 — — CN disclosed
WO-2001089457-A2 THROMBOPOIETIN MIMETICS SMITHKLINE BEECHAM CORPORATION (US) 2001-11-29 — — WO disclosed
US-5847231-A Selective nitration of phenol derivatives JUNSEI CHEMICAL CO., LTD. (JP) 1998-12-08 — — US disclosed
CN-1174829-A Selective nitration of phenol derivatives JUNSEI CHEMICAL (JP) 1998-03-04 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12421206-B2 Aryl-n-aryl derivatives for treating a RNA virus infection NSUN3, CBR3, C1R BACE1 4311/4885EGFR 1138/4885GPR35 2682/4885
US-20260035348-A1 PHENYL-N-QUINOLINE DERIVATIVES FOR TREATING A RNA VIRUS INFECTION SARS1, NDUFC2, CLIC1 BACE1 4065/4885EGFR 3701/4885GPR35 4855/4885
US-12384788-B2 1,4-dihydrobenzo[d]pyrazolo[3,4-f][1,3]diazepine derivatives and related compounds as LRRK2, NUAK1 and/or TYK2 kinase modulators for the treatment of e.g. autoimmune disease NUAK1, TYK2, MARK1 BACE1 244/4885EGFR 961/4885GPR35 975/4885
US-20220372008-A1 LUCIFERIN DERIVATIVES AND A METHOD FOR SYNTHESIS THEREOF NQO1, DDT, GLO1 BACE1 1237/4885EGFR 4296/4885GPR35 2563/4885
US-20250361237-A1 1,4-DIHYDROBENZO[D]PYRAZOLO[3,4-F][1,3]DIAZEPINE DERIVATIVES AND RELATED COMPOUNDS AS LRRK2, NUAK1 AND/OR TYK2 KINASE MODULATORS FOR THE TREATMENT OF E.G. AUTOIMMUNE DISEASE NUAK1, TYK2, MARK1 BACE1 244/4885EGFR 961/4885GPR35 975/4885
US-12479802-B2 Phenyl-n-quinoline derivatives for treating a RNA virus infection ORC3, NSUN3, POLR2H BACE1 4412/4885EGFR 3754/4885GPR35 3873/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.