Sugi Predict

Sugi Predict / Compounds / SCHEMBL22918396

SCHEMBL22918396

SCHEMBL22918396

COc1cc(Br)c(F)cc1C=O

nearest known ligand 0.63

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ PRKDC P78527 2/20 0.63
▸ ALDH1A1 P00352 7/20 0.59
▸ KDM4E B2RXH2 2/20 0.59
▸ TSHR P16473 1/20 0.59
▸ TDP1 Q9NUW8 1/20 0.59
▸ ERN1 O75460 7/20 0.47
▸ LMNA P02545 3/20 0.47
▸ HPGD P15428 2/20 0.47
▸ MAPT P10636 3/20 0.44
▸ L3MBTL1 Q9Y468 3/20 0.44
▸ SMN1; SMN2 Q16637 2/20 0.43
▸ GAA P10253 1/20 0.41
▸ CYP3A4 P08684 1/20 0.40
▸ ALOX15 P16050 1/20 0.40
▸ HSD17B10 Q99714 1/20 0.40
▸ POLB P06746 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30316242 0.94 ALDH1A1 (0.57) PRKDCALDH1A1KDM4ETSHRTDP1
SCHEMBL4600427 0.94 ALDH1A1 (0.57) PRKDCALDH1A1KDM4ETSHRTDP1
SCHEMBL16411776 0.85 PRKDC (0.75) PRKDCALDH1A1KDM4ETSHRTDP1
SCHEMBL2037836 0.84 PRKDC (0.74) PRKDCALDH1A1KDM4ETSHRTDP1
SCHEMBL29950688 0.84 ALDH1A1 (0.68) PRKDCALDH1A1KDM4ETSHRTDP1
SCHEMBL4813783 0.84 ALDH1A1 (0.68) PRKDCALDH1A1KDM4ETSHRTDP1
SCHEMBL15031973 0.81 PRKDC (0.63) PRKDCALDH1A1KDM4ETSHRTDP1
SCHEMBL31456072 0.81 PRKDC (0.63) PRKDCALDH1A1KDM4ETSHRTDP1
SCHEMBL1539323 0.80 ALDH1A1 (0.69) PRKDCALDH1A1KDM4ETSHRTDP1
SCHEMBL20488498 0.80 ALDH1A1 (0.69) PRKDCALDH1A1KDM4ETSHRTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250177539-A1 ER DEGRADERS AND USES THEREOF ASTRAZENECA AB (SE) 2025-06-05 — — US disclosed
EP-4291235-A1 HPK1 ANTAGONISTS AND USES THEREOF Nimbus Saturn, Inc. (US) 2023-12-20 — — EP disclosed
CN-117120090-A HPK1 antagonists and uses thereof 林伯士萨顿公司 2023-11-24 — — CN disclosed
US-20230096641-A1 HPK1 ANTAGONISTS AND USES THEREOF NIMBUS DISCOVERY, INC. 2023-03-30 — — US disclosed
WO-2022174253-A1 HPK1 ANTAGONISTS AND USES THEREOF Nimbus Saturn, Inc. (US) 2022-08-18 — — WO disclosed
WO-2022174253-A1 HPK1 ANTAGONISTS AND USES THEREOF Nimbus Saturn, Inc. (US) 2022-08-18 — — WO disclosed
US-20220235006-A1 PYRIDINE DERIVATIVES AS TMEM16A MODULATORS FOR USE IN THE TREATMENT OF RESPIRATORY CONDITIONS Enterprise Therapeutics Limited (GB) 2022-07-28 — — US disclosed
WO-2021014166-A1 PYRIDINE DERIVATIVES AS TMEM16A MODULATORS FOR USE IN THE TREATMENT OF RESPIRATORY CONDITIONS Enterprise Therapeutics Limited (GB) 2021-01-28 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230096641-A1 HPK1 ANTAGONISTS AND USES THEREOF PDXK, HIPK1, PCK1 PRKDC 152/4885ALDH1A1 4740/4885KDM4E 3143/4885
US-20250177539-A1 ER DEGRADERS AND USES THEREOF ESR1, ESR2, ESRRA PRKDC 4679/4885ALDH1A1 1672/4885KDM4E 598/4885
US-20220235006-A1 PYRIDINE DERIVATIVES AS TMEM16A MODULATORS FOR USE IN THE TREATMENT OF RESPIRATORY CONDITIONS TMEM109, TMEM70, TMEM120A PRKDC 4856/4885ALDH1A1 496/4885KDM4E 3158/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.