Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH3A1 | P30838 | 5/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.61 |
| ▸ | ALDH1A3 | P47895 | 4/20 | 0.61 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.33 |
| ▸ | FDPS | P14324 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2163891 | 0.85 | ALDH1A1 (0.46) | ALDH3A1ALDH1A1ALDH1A3 | |
| SCHEMBL16731702 | 0.80 | ALDH1A3 (0.46) | ALDH3A1ALDH1A1ALDH1A3TSHRFDPS | |
| SCHEMBL6185779 | 0.79 | ALDH1A1 (0.45) | ALDH3A1ALDH1A1ALDH1A3TSHRFDPS | |
| SCHEMBL13630983 | 0.74 | ALDH1A1 (0.40) | ALDH3A1ALDH1A1ALDH1A3TSHRFDPS | |
| SCHEMBL20133582 | 0.72 | TSHR (0.42) | ALDH3A1ALDH1A1ALDH1A3ARTSHR | |
| SCHEMBL6899726 | 0.70 | ALDH1A1 (0.47) | ALDH1A1TSHRFDPS | |
| SCHEMBL13571237 | 0.70 | ALDH1A1 (0.39) | ALDH3A1ALDH1A1ALDH1A3ARTSHR | |
| SCHEMBL13571069 | 0.70 | ALDH1A1 (0.37) | ALDH3A1ALDH1A1ALDH1A3ARTSHR | |
| SCHEMBL13123327 | 0.70 | ALDH1A3 (0.43) | ALDH3A1ALDH1A1ALDH1A3TSHRMAPT | |
| SCHEMBL177342 | 0.70 | FDPS (0.54) | ALDH1A1ARTSHRFDPSMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554245-B1 | PIPERIDINETRIOL DERIVATIVES AS INHIBITORS OF GLYCOSYLCERAMIDSYNTHASE | ACTELION PHARMACEUTICALS LTD (CH) | 2012-09-26 | — | — | EP | disclosed |
| US-7994198-B2 | Piperidinetriol derivatives as inhibitors of glycosylceramidsynthase | ACTELION PHARMACEUTICALS LTD. (CH) | 2011-08-09 | — | — | US | disclosed |
| US-20060111400-A1 | Piperidinetriol derivatives as inhibitors of glycosylceramidsynthase | OXFORD GLYCOSCIENCES (UK) LTD (GB) | 2006-05-25 | — | — | US | disclosed |
| EP-1554245-A1 | PIPERIDINETRIOL DERIVATIVES AS INHIBITORS OF GLYCOSYLCERAMIDSYNTHASE | Oxford GlycoSciences (UK) Ltd (GB) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004007454-A1 | PIPERIDINETRIOL DERIVATIVES AS INHIBITORS OF GLYCOSYLCERAMIDSYNTHASE | OXFORD GLYCOSCIENCES (UK) LTD (GB) | 2004-01-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060111400-A1 | Piperidinetriol derivatives as inhibitors of glycosylceramidsynthase | GBA1, UGCG, CERS2 | ALDH3A1 678/4885ALDH1A1 790/4885ALDH1A3 1437/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.