SCHEMBL2292191

SCHEMBL2292191

COc1cc(C)nc(Cc2cccc(F)c2N)n1

nearest known ligand 0.43

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
SLC6A3 Q01959 1/20 0.41
TSHR P16473 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
HTT P42858 2/20 0.37
L3MBTL1 Q9Y468 1/20 0.36
PDE2A O00408 1/20 0.36
CHRM4 P08173 2/20 0.35
ALDH1A1 P00352 2/20 0.35
HTR6 P50406 1/20 0.34
LMNA P02545 2/20 0.33
NPC1 O15118 1/20 0.33
CYP1A2 P05177 1/20 0.33
RAB9A P51151 1/20 0.33
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
KDM4E B2RXH2 1/20 0.33
MAPK1 P28482 1/20 0.33
ADORA2A P29274 1/20 0.33
ADORA1 P30542 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2283366 0.92 PDE2A (0.39) PDE2AALDH1A1HTR6NPC1CYP1A2
SCHEMBL2290194 0.87 HTR6 (0.39) HTTL3MBTL1CHRM4HTR6LMNA
SCHEMBL5504260 0.87 SMN1; SMN2 (0.40) TSHRSMN1; SMN2L3MBTL1CHRM4ALDH1A1
SCHEMBL2286122 0.84 HSP90AA1 (0.43) SLC6A3TSHRSMN1; SMN2HTTPDE2A
SCHEMBL2285461 0.84 GAA (0.41) L3MBTL1PDE2AHTR6LMNANPC1
SCHEMBL5499313 0.80 NPC1 (0.35) PDE2AALDH1A1NPC1CYP1A2RAB9A
SCHEMBL2289349 0.79 HTR6 (0.38) HTR6LMNANPC1CYP1A2RAB9A
SCHEMBL2286222 0.77 SLC6A3 (0.39) SLC6A3TSHRSMN1; SMN2HTTPDE2A
SCHEMBL3775535 0.76 ALDH1A1 (0.43) TSHRHTTL3MBTL1PDE2AALDH1A1
SCHEMBL3736038 0.75 PDE2A (0.39) L3MBTL1PDE2AALDH1A1HTR6NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1773124-B1 A USE OF SULFONANILIDES AS AGRICULTURAL AND HORTICULTURAL FUNGICIDE BAYER CROPSCIENCE AG (DE) 2012-08-22 EP disclosed
US-8008484-B2 Use of sulfonanilides as agricultural and horticultural fungicide BAYER CROPSCIENCE AG (DE) 2011-08-30 US disclosed
US-20070219199-A1 Use of Sulfonanilides as Agricultural and Horticultural Fungicide BAYER CROPSCIENCE AG (DE) 2007-09-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070219199-A1 Use of Sulfonanilides as Agricultural and Horticultural Fungicide CBR3, CYP51A1, CBR1 SLC6A3 2898/4885TSHR 800/4885SMN1; SMN2 3491/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.