Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 1/20 | 0.66 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.63 |
| ▸ | FLT3 | P36888 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | HPGD | P15428 | 5/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.53 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.53 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | ALPL | P05186 | 1/20 | 0.51 |
| ▸ | IDO1 | P14902 | 1/20 | 0.51 |
| ▸ | TTK | P33981 | 1/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.49 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4488472 | 0.78 | KDM4E (0.74) | MAP2K4ALDH1A1HPGDMAPTL3MBTL1 | |
| SCHEMBL3732433 | 0.78 | MAP2K4 (1.00) | ITKMAP2K4ALDH1A1HPGDMAPK8 | |
| Hydrochloric Acid SCHEMBL1595834 | 0.78 | FLT3 (0.56) | ITKMAP2K4FLT3ALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL1595838 | 0.78 | FLT3 (0.56) | ITKMAP2K4FLT3ALDH1A1HPGD | |
| Propionic Acid SCHEMBL4552403 | 0.77 | KDM4E (0.71) | MAP2K4FLT3ALDH1A1HPGDMAPK8 | |
| SCHEMBL8126956 | 0.76 | MAPK1 (0.72) | MAP2K4FLT3ALDH1A1HPGDMAPK8 | |
| SCHEMBL22926418 | 0.75 | ALDH1A1 (0.56) | ALDH1A1HPGDMAPTL3MBTL1GAA | |
| SCHEMBL2194210 | 0.74 | MAPK8 (0.61) | MAP2K4FLT3ALDH1A1HPGDMAPK8 | |
| SCHEMBL12422528 | 0.74 | MAPK8 (0.78) | MAP2K4FLT3MAPK8KDM4EGAA | |
| SCHEMBL4444933 | 0.74 | HPGD (1.00) | ALDH1A1HPGDMAPTL3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3587406-B1 | 2-HYDROXY-1-{4-[(4-PHENYLPHENYL)CARBONYL]PIPERAZIN-1-YL}ETHAN-1-ONE DERIVATIVES AND RELATED COMPOUNDS AS FATTY ACID SYNTHASE (FASN) INHIBITORS FOR THE TREATMENT OF CANCER | FORMA THERAPEUTICS INC (US) | 2021-01-27 | — | — | EP | disclosed |