Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.71 |
| ▸ | TTK | P33981 | 3/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.71 |
| ▸ | IDO1 | P14902 | 2/20 | 0.71 |
| ▸ | ALPL | P05186 | 1/20 | 0.71 |
| ▸ | GAA | P10253 | 1/20 | 0.71 |
| ▸ | HPGD | P15428 | 1/20 | 0.71 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.71 |
| ▸ | MAP2K4 | P45985 | 3/20 | 0.65 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.60 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.60 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.55 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 5/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30768403 | 0.84 | ALDH1A1 (1.00) | KDM4ETTKALDH1A1IDO1ALPL | |
| SCHEMBL855531 | 0.84 | ALDH1A1 (1.00) | KDM4ETTKALDH1A1IDO1ALPL | |
| Acetic Acid Methyl Ester SCHEMBL15622680 | 0.83 | KDM4E (0.69) | KDM4ETTKALDH1A1IDO1ALPL | |
| SCHEMBL22819499 | 0.81 | MAP2K4 (0.66) | KDM4ETTKALDH1A1IDO1ALPL | |
| SCHEMBL17178615 | 0.81 | ALDH1A1 (0.92) | KDM4ETTKALDH1A1IDO1ALPL | |
| SCHEMBL3732433 | 0.79 | MAP2K4 (1.00) | KDM4ETTKALDH1A1IDO1ALPL | |
| SCHEMBL27968462 | 0.78 | ALDH1A1 (0.85) | KDM4ETTKALDH1A1IDO1ALPL | |
| SCHEMBL22926176 | 0.77 | ITK (0.66) | KDM4ETTKALDH1A1IDO1ALPL | |
| SCHEMBL4488472 | 0.77 | KDM4E (0.74) | KDM4ETTKALDH1A1IDO1ALPL | |
| SCHEMBL22801827 | 0.75 | MAP2K4 (1.00) | KDM4ETTKALDH1A1IDO1ALPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8785474-B2 | Vanilloid receptor ligands, pharmaceutical compositions containing them, process for making them, and use thereof to treat pain and other conditions | GRUENENTHAL GMBH (DE) | 2014-07-22 | — | — | US | disclosed |
| US-8084484-B2 | Vanilloid receptor ligands, pharmaceutical compositions containing them, process for making them, and use thereof for treating pain and other conditions | GRUENENTHAL GMBH (DE) | 2011-12-27 | — | — | US | disclosed |
| US-20110301156-A1 | Vanilloid Receptor Ligands, Pharmaceutical Compositions Containing Them, Process For Making Them, and Use Thereof to Treat Pain and Other Conditions | GRUENENTHAL GMBH (DE) | 2011-12-08 | — | — | US | disclosed |
| US-20090156590-A1 | Vanilloid Receptor Ligands, Pharmaceutical Compositions Containing Them, Process for Making Them, and Use Thereof for Treating Pain and Other Conditions | GRUENENTHAL GMBH (DE) | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156590-A1 | Vanilloid Receptor Ligands, Pharmaceutical Compositions Containing Them, Process for Making Them, and Use Thereof for Treating Pain and Other Conditions | TRPV1, OPRL1, TRPV2 | KDM4E 4459/4885TTK 4160/4885ALDH1A1 1590/4885 |
| US-20110301156-A1 | Vanilloid Receptor Ligands, Pharmaceutical Compositions Containing Them, Process For Making Them, and Use Thereof to Treat Pain and Other Conditions | TRPV1, OPRL1, TRPV2 | KDM4E 4441/4885TTK 4236/4885ALDH1A1 1566/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.