Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.42 |
| ▸ | GRM1 | Q13255 | 8/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 8/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.40 |
| ▸ | ATR | Q13535 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | CKS1B | P61024 | 1/20 | 0.38 |
| ▸ | SKP1 | P63208 | 1/20 | 0.38 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL609042 | 0.88 | NAMPT (0.44) | NAMPTPDK4GRM1CYP11B2GRM5 | |
| SCHEMBL29538449 | 0.88 | NAMPT (0.44) | NAMPTPDK4GRM1CYP11B2GRM5 | |
| SCHEMBL21245626 | 0.85 | ALDH1A1 (0.41) | NAMPTPDK4GRM1CYP11B2GRM5 | |
| SCHEMBL29813606 | 0.85 | ALDH1A1 (0.41) | NAMPTPDK4GRM1CYP11B2GRM5 | |
| SCHEMBL23554461 | 0.84 | TNF (0.44) | NAMPTPDK4GRM1CYP11B2GRM5 | |
| SCHEMBL29550046 | 0.84 | TNF (0.44) | NAMPTPDK4GRM1CYP11B2GRM5 | |
| SCHEMBL29220909 | 0.83 | GPR119 (0.54) | NAMPTPDK4GRM1CYP11B2GRM5 | |
| SCHEMBL31639966 | 0.82 | CYP11B2 (0.42) | NAMPTPDK4GRM1ESR2CYP11B2 | |
| SCHEMBL21767846 | 0.81 | NAMPT (0.52) | NAMPTPDK4GRM1ESR2GRM5 | |
| SCHEMBL29550169 | 0.81 | GPR119 (0.41) | NAMPTPDK4GRM1CYP11B2GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210024498-A1 | TETRAHYDROPYRROLE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND USE THEREOF | MEDICONNS SHANGHAI BIOPHARMACEUTICAL CO LTD (CN) | 2021-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210024498-A1 | TETRAHYDROPYRROLE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND USE THEREOF | PRLHR, DRD2, AVPR2 | NAMPT 3605/4885PDK4 1190/4885GRM1 425/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.