Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | NOS3 | P29474 | 2/20 | 0.36 |
| ▸ | NOS2 | P35228 | 2/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | CCR1 | P32246 | 1/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | CCR8 | P51685 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | APLNR | P35414 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | TTK | P33981 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17946845 | 0.78 | NOS3 (0.36) | CYP3A4NOS3NOS2NOS1CCR1 | |
| SCHEMBL30975066 | 0.78 | TDP1 (0.38) | CYP3A4NOS3NOS2NOS1CCR1 | |
| SCHEMBL21552375 | 0.78 | TDP1 (0.38) | CYP3A4NOS3NOS2NOS1CCR1 | |
| SCHEMBL6792963 | 0.77 | NOS3 (0.48) | NOS3NOS2NOS1CCR1CCR5 | |
| SCHEMBL16618427 | 0.77 | NOS3 (0.35) | CYP3A4NOS3NOS2NOS1CCR1 | |
| SCHEMBL10201420 | 0.77 | NOS3 (0.35) | CYP3A4NOS3NOS2NOS1CCR1 | |
| SCHEMBL31289813 | 0.77 | HPGD (0.40) | CYP3A4NOS3NOS2NOS1CCR1 | |
| SCHEMBL4074890 | 0.76 | ALDH1A1 (0.44) | CYP3A4CCR1CCR5CCR8ALDH1A1 | |
| SCHEMBL18686676 | 0.75 | ENPP2 (0.36) | NOS3NOS2NOS1CCR1CCR5 | |
| SCHEMBL22972330 | 0.74 | TRPA1 (0.37) | CYP3A4NOS3NOS2NOS1CCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3380101-B1 | EIF4-A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO | EFFECTOR THERAPEUTICS INC (US) | 2021-01-27 | — | — | EP | disclosed |