Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 5/20 | 0.48 |
| ▸ | TRPV6 | Q9H1D0 | 2/20 | 0.48 |
| ▸ | CES2 | O00748 | 1/20 | 0.48 |
| ▸ | CES1 | P23141 | 1/20 | 0.48 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.48 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.48 |
| ▸ | ORAI3 | Q9BRQ5 | 1/20 | 0.48 |
| ▸ | MGLL | Q99685 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.43 |
| ▸ | HTR3B | O95264 | 1/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.43 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2375798 | 0.85 | MEN1 (0.48) | ALDH1A1TSHR | |
| SCHEMBL1536352 | 0.83 | KIF11 (0.48) | KIF11TRPV6CES2CES1ORAI1 | |
| SCHEMBL27973991 | 0.83 | KIF11 (0.48) | KIF11TRPV6CES2CES1ORAI1 | |
| SCHEMBL20149638 | 0.82 | ALDH1A1 (0.50) | KIF11TRPV6CES2CES1ORAI1 | |
| SCHEMBL677817 | 0.79 | ALDH1A1 (0.53) | KIF11TRPV6CES2CES1ORAI1 | |
| SCHEMBL3239844 | 0.79 | KIF11 (0.44) | KIF11TRPV6CES2CES1ORAI1 | |
| SCHEMBL13644373 | 0.79 | ESR1 (0.58) | — | |
| SCHEMBL63468 | 0.78 | ALDH1A1 (0.67) | KIF11TRPV6CES2CES1ORAI1 | |
| SCHEMBL8071364 | 0.78 | HSD11B1 (0.52) | TRPV6ORAI1ORAI2ORAI3ALDH1A1 | |
| SCHEMBL14703793 | 0.77 | ALDH1A1 (0.50) | KIF11TRPV6CES2CES1ORAI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3888658-A1 | EIF4-A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO | Effector Therapeutics Inc. (US) | 2021-10-06 | — | — | EP | disclosed |
| EP-3380101-B1 | EIF4-A-INHIBITING COMPOUNDS AND METHODS RELATED THERETO | EFFECTOR THERAPEUTICS INC (US) | 2021-01-27 | — | — | EP | disclosed |