Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 6/20 | 0.51 |
| ▸ | TGM2 | P21980 | 6/20 | 0.50 |
| ▸ | MAOA | P21397 | 6/20 | 0.47 |
| ▸ | MAOB | P27338 | 6/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | CASP2 | P42575 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | GLB1 | P16278 | 1/20 | 0.37 |
| ▸ | CTRC | Q99895 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8714236 | 0.86 | CES1 (0.55) | CES1TGM2MAOAMAOBBCHE | |
| SCHEMBL30398896 | 0.74 | CES1 (0.62) | CES1TGM2MAOAMAOBBCHE | |
| SCHEMBL4192180 | 0.74 | CES1 (0.62) | CES1TGM2MAOAMAOBBCHE | |
| SCHEMBL22961903 | 0.71 | HPGD (0.44) | CES1TGM2MAOAMAOBALDH1A1 | |
| SCHEMBL4444879 | 0.71 | TGM2 (0.55) | CES1TGM2MAOAMAOBALDH1A1 | |
| SCHEMBL11701605 | 0.71 | CES1 (0.50) | CES1TGM2MAOAMAOBBCHE | |
| SCHEMBL13594800 | 0.71 | MAOA (0.58) | CES1TGM2MAOAMAOBBCHE | |
| SCHEMBL9498049 | 0.71 | ELANE (0.53) | CES1MAOABCHEALDH1A1CASP3 | |
| SCHEMBL29721579 | 0.71 | ELANE (0.53) | CES1MAOABCHEALDH1A1CASP3 | |
| SCHEMBL16111115 | 0.70 | CES1 (0.53) | CES1TGM2MAOAMAOBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210024498-A1 | TETRAHYDROPYRROLE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND USE THEREOF | MEDICONNS SHANGHAI BIOPHARMACEUTICAL CO LTD (CN) | 2021-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210024498-A1 | TETRAHYDROPYRROLE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND USE THEREOF | PRLHR, DRD2, AVPR2 | CES1 2454/4885TGM2 3786/4885MAOA 1717/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.