Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.51 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.51 |
| ▸ | CXCR6 | O00574 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 3/20 | 0.48 |
| ▸ | DRD2 | P14416 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.46 |
| ▸ | CKS1B | P61024 | 1/20 | 0.46 |
| ▸ | SKP1 | P63208 | 1/20 | 0.46 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29670060 | 1.00 | HRH4 (0.51) | HRH4KCNA3CXCR6PARP1DRD2 | |
| SCHEMBL22928907 | 0.80 | AKR1C3 (0.61) | HRH4PARP1MCL1 | |
| SCHEMBL4117894 | 0.80 | MCHR1 (0.65) | — | |
| SCHEMBL23964249 | 0.79 | HRH4 (0.60) | HRH4PARP1DRD2KMT2AMEN1 | |
| SCHEMBL915402 | 0.79 | KMT2A (0.65) | KCNA3DRD2KMT2AMEN1L3MBTL1 | |
| SCHEMBL7549641 | 0.75 | KCNA3 (0.59) | KCNA3DRD2KMT2AMEN1L3MBTL1 | |
| SCHEMBL12533621 | 0.75 | SIGMAR1 (0.63) | KCNA3DRD2KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL555464 | 0.75 | KMT2A (0.64) | KCNA3DRD2KMT2AMEN1L3MBTL1 | |
| SCHEMBL16203503 | 0.74 | ALDH1A1 (0.53) | KCNA3KMT2AMEN1ALDH1A1L3MBTL1 | |
| SCHEMBL31653778 | 0.74 | KCNA3 (0.48) | KCNA3PARP1DRD2KMT2APARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11365195-B2 | Atypical inhibitors of monoamine transporters; method of making; and use thereof | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2022-06-21 | — | — | US | disclosed |
| US-20210024523-A1 | ATYPICAL INHIBITORS OF MONOAMINE TRANSPORTERS; METHOD OF MAKING; AND USE THEREOF | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2021-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210024523-A1 | ATYPICAL INHIBITORS OF MONOAMINE TRANSPORTERS; METHOD OF MAKING; AND USE THEREOF | SLC18A2, SLC6A3, SLC6A4 | HRH4 1705/4885KCNA3 1030/4885CXCR6 2264/4885 |
| US-11365195-B2 | Atypical inhibitors of monoamine transporters; method of making; and use thereof | SLC18A2, SLC6A3, SLC6A4 | HRH4 1705/4885KCNA3 1030/4885CXCR6 2264/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.