Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YAP1 | P46937 | 13/20 | 0.65 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.45 |
| ▸ | GLS | O94925 | 1/20 | 0.44 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.43 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19982220 | 0.90 | YAP1 (0.77) | YAP1ITGB1ITGA4 | |
| SCHEMBL19982219 | 0.90 | YAP1 (0.77) | YAP1ITGB1ITGA4 | |
| SCHEMBL19982213 | 0.82 | YAP1 (0.85) | YAP1GPR119 | |
| SCHEMBL19982212 | 0.82 | YAP1 (0.85) | YAP1GPR119 | |
| SCHEMBL22929132 | 0.80 | YAP1 (0.47) | YAP1 | |
| SCHEMBL19982071 | 0.79 | YAP1 (1.00) | YAP1 | |
| SCHEMBL25754096 | 0.78 | YAP1 (0.79) | YAP1ITGB1ITGA4GPR119 | |
| SCHEMBL13282013 | 0.78 | MAOB (0.53) | TGFBR1GPR119 | |
| SCHEMBL19974617 | 0.77 | YAP1 (0.65) | YAP1 | |
| SCHEMBL19974618 | 0.77 | YAP1 (0.65) | YAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10906874-B2 | YAP1 inhibitors that target the interaction of YAP1 with OCT4 | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2021-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10906874-B2 | YAP1 inhibitors that target the interaction of YAP1 with OCT4 | YAP1, IWS1, YES1 | YAP1 1/4885TGFBR1 3542/4885GLS 3378/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.