Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | NAAA | Q02083 | 1/20 | 0.56 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.51 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.51 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.48 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.48 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7371370 | 1.00 | ATM (0.59) | ATMMEN1KMT2AL3MBTL1TDP1 | |
| SCHEMBL25447312 | 0.91 | HSD11B1 (0.57) | ATMMEN1KMT2AL3MBTL1TDP1 | |
| SCHEMBL2828741 | 0.88 | MEN1 (0.74) | ATMMEN1KMT2AL3MBTL1TDP1 | |
| SCHEMBL12128801 | 0.88 | MEN1 (0.74) | ATMMEN1KMT2AL3MBTL1TDP1 | |
| SCHEMBL5517503 | 0.87 | HSD11B1 (0.70) | ATMMEN1KMT2AHSD11B1TP53 | |
| SCHEMBL3952911 | 0.87 | HSD11B1 (0.70) | ATMMEN1KMT2AHSD11B1TP53 | |
| SCHEMBL4382097 | 0.85 | KMT2A (0.59) | ATMMEN1KMT2ANAAAHSD11B1 | |
| SCHEMBL4382883 | 0.85 | KMT2A (0.59) | ATMMEN1KMT2ANAAAHSD11B1 | |
| SCHEMBL7217209 | 0.85 | TP53 (0.71) | ATMMEN1KMT2AHSD11B1TP53 | |
| SCHEMBL14218032 | 0.84 | HSD11B1 (0.81) | ATMMEN1KMT2AL3MBTL1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021018018-A1 | DEGRADATION OF BRUTON'S TYROSINE KINASE (BTK) BY CONJUGATION OF BTK INIDBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | BEIGENE, LTD. (KY) | 2021-02-04 | — | — | WO | disclosed |