Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.81 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.55 |
| ▸ | NAAA | Q02083 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | GNAI3 | P08754 | 2/20 | 0.48 |
| ▸ | GNAO1 | P09471 | 2/20 | 0.48 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.48 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.45 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22940447 | 0.84 | ATM (0.59) | HSD11B1SIGMAR1NAAAALDH1A1ATM | |
| SCHEMBL7371370 | 0.84 | ATM (0.59) | HSD11B1SIGMAR1NAAAALDH1A1ATM | |
| SCHEMBL4377326 | 0.82 | HSD11B1 (0.55) | HSD11B1SIGMAR1NAAAALDH1A1ATM | |
| SCHEMBL4382883 | 0.81 | KMT2A (0.59) | HSD11B1SIGMAR1NAAAALDH1A1ATM | |
| SCHEMBL4382097 | 0.81 | KMT2A (0.59) | HSD11B1SIGMAR1NAAAALDH1A1ATM | |
| SCHEMBL25447312 | 0.79 | HSD11B1 (0.57) | HSD11B1NAAAALDH1A1ATMTP53 | |
| SCHEMBL4382989 | 0.78 | HSD11B1 (0.78) | HSD11B1ALDH1A1ATMTP53GAA | |
| SCHEMBL23471439 | 0.77 | L3MBTL1 (0.69) | HSD11B1NAAAALDH1A1L3MBTL1MEN1 | |
| SCHEMBL12128801 | 0.77 | MEN1 (0.74) | HSD11B1SIGMAR1NAAAALDH1A1ATM | |
| SCHEMBL2828741 | 0.77 | MEN1 (0.74) | HSD11B1SIGMAR1NAAAALDH1A1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080113968-A1 | Substituted piperazines and diazepanes | NOVO NORDISK A/S (DK) | 2008-05-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080113968-A1 | Substituted piperazines and diazepanes | HRH3, HRH4, HRH1 | HSD11B1 2071/4885SIGMAR1 237/4885NAAA 1136/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.