Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | NAAA | Q02083 | 1/20 | 0.49 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.48 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.45 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.45 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12128801 | 1.00 | MEN1 (0.74) | MEN1KMT2AALDH1A1KDM4EMAPT | |
| SCHEMBL4382883 | 0.90 | KMT2A (0.59) | MEN1KMT2AALDH1A1KDM4EMAPT | |
| SCHEMBL4382097 | 0.90 | KMT2A (0.59) | MEN1KMT2AALDH1A1KDM4EMAPT | |
| SCHEMBL22940447 | 0.88 | ATM (0.59) | MEN1KMT2AALDH1A1NAAAITGB3 | |
| SCHEMBL7371370 | 0.88 | ATM (0.59) | MEN1KMT2AALDH1A1NAAAITGB3 | |
| SCHEMBL1334264 | 0.81 | MEN1 (0.68) | MEN1KMT2AMAPTTDP1L3MBTL1 | |
| SCHEMBL8142577 | 0.80 | MEN1 (0.62) | MEN1KMT2AALDH1A1KDM4EMAPT | |
| SCHEMBL7080193 | 0.80 | MEN1 (0.55) | MEN1KMT2AMAPTTDP1L3MBTL1 | |
| SCHEMBL25447312 | 0.79 | HSD11B1 (0.57) | MEN1KMT2AALDH1A1NAAAITGB3 | |
| SCHEMBL14218032 | 0.77 | HSD11B1 (0.81) | MEN1KMT2AALDH1A1MAPTNAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | claimed |
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | disclosed |
| EP-2243776-A1 | Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2010-10-27 | — | — | EP | disclosed |
| US-7064135-B2 | Substituted piperidines | NOVO NORDISK INC. (DK) | 2006-06-20 | — | — | US | disclosed |