SCHEMBL22942018

SCHEMBL22942018

CC#Cc1cc(C)c(C2C(=O)CC3(CCC(C(=O)N4CCN(C(C)=O)CC4)CC3)CC2=O)c(C)c1

nearest known ligand 0.33

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
RORC P51449 1/20 0.32
CNR1 P21554 1/20 0.32
ACACB O00763 6/20 0.32
ACACA Q13085 6/20 0.32
GAA P10253 1/20 0.31
MMP2 P08253 1/20 0.31
MMP13 P45452 1/20 0.31
TSHR P16473 1/20 0.31
CNR2 P34972 1/20 0.31
ITGB3 P05106 1/20 0.30
ITGA2B P08514 1/20 0.30
BRD4 O60885 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21332010 0.90 ALDH1A1 (0.34) CNR1GAAITGB3ITGA2BBRD4
SCHEMBL21274392 0.88 USP2 (0.35) TSHR
SCHEMBL22942019 0.88 RORC (0.33) RORC
SCHEMBL22992014 0.88 BRD4 (0.37) CNR1TSHRBRD4
SCHEMBL22907757 0.86 CYP2D6 (0.35) TSHR
SCHEMBL22992046 0.85 EPHX2 (0.36) CNR2
SCHEMBL22955488 0.84 ACACB (0.33) CNR1ACACBACACATSHRCNR2
SCHEMBL23748395 0.83 MGLL (0.32)
SCHEMBL21344743 0.83 MGLL (0.33)
SCHEMBL22992234 0.82 GAA (0.38) GAATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021018834-A1 CYCLIC DIONES AS HERBICIDAL COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2021-02-04 WO disclosed