SCHEMBL22945890

SCHEMBL22945890

Cn1nc(C2CC2)c(C(=O)c2ccc(Cl)c(CN3CCS(=O)(=O)CC3)c2Cl)c1OCC(=O)c1ccccc1

nearest known ligand 0.34

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
HSD11B1 P28845 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP2C19 P33261 1/20 0.31
KMT2A Q03164 1/20 0.31
BCHE P06276 1/20 0.30
ACHE P22303 1/20 0.30
USP2 O75604 1/20 0.30
NR3C1 P04150 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22945896 0.94 CNR1 (0.31)
SCHEMBL22945895 0.93 MEN1 (0.35) KMT2A
SCHEMBL22946152 0.90 MAPT (0.37) KMT2AUSP2
SCHEMBL30423372 0.90 MAPT (0.37) KMT2AUSP2
SCHEMBL22946181 0.90 ALDH1A1 (0.32) BCHEACHEUSP2NR3C1
SCHEMBL22945894 0.89 ABCB1 (0.38) HSD11B1CYP1A2CYP2C19KMT2ANR3C1
SCHEMBL22945856 0.87 TSHR (0.32) HSD11B1CYP1A2CYP2C19KMT2A
SCHEMBL22946319 0.86 ALDH1A1 (0.36) KMT2A
SCHEMBL22946173 0.83 SMN1; SMN2 (0.31)
SCHEMBL23061048 0.83 BDKRB2 (0.32)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021018135-A1 HETEROCYCLYL ALKYL SUBSTITUTED DICHLOROBENZOYL COMPOUNDS AND APPLICATIONS THEREOF 东莞市东阳光农药研发有限公司 2021-02-04 WO disclosed