Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 3/20 | 0.70 |
| ▸ | LMNA | P02545 | 1/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.70 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | ABCG2 | Q9UNQ0 | 7/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.49 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.49 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.49 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | EDNRA | P25101 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11246892 | 0.99 | GPR35 (0.72) | GPR35LMNATDP1MEN1KMT2A | |
| SCHEMBL11247900 | 0.99 | GPR35 (0.72) | GPR35LMNATDP1MEN1KMT2A | |
| SCHEMBL11250063 | 0.99 | GPR35 (0.72) | GPR35LMNATDP1MEN1KMT2A | |
| SCHEMBL11245442 | 0.99 | GPR35 (0.72) | GPR35LMNATDP1MEN1KMT2A | |
| SCHEMBL11253078 | 0.99 | GPR35 (0.72) | GPR35LMNATDP1MEN1KMT2A | |
| SCHEMBL11248651 | 0.97 | GPR35 (0.74) | GPR35LMNATDP1MEN1KMT2A | |
| SCHEMBL11142080 | 0.94 | GPR35 (0.74) | GPR35LMNATDP1MEN1KMT2A | |
| SCHEMBL11244502 | 0.93 | GPR35 (0.76) | GPR35LMNATDP1MEN1KMT2A | |
| SCHEMBL9847108 | 0.92 | GPR35 (0.65) | GPR35LMNATDP1MEN1KMT2A | |
| SCHEMBL9847173 | 0.92 | GPR35 (0.65) | GPR35LMNATDP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110195924-A1 | Methods of Inhibiting the Interaction Between S100P and the Receptor for Advanced Glycation End-Products | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2011-08-11 | — | — | US | claimed |
| WO-2010042504-A1 | METHODS OF INHIBITING THE INTERACTION BETWEEN S100 AND THE RECEPTOR FOR ADVANCED GLYCATION END-PRODUCTS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2010-04-15 | — | — | WO | claimed |
| US-20090062319-A1 | METHODS OF INHIBITING THE INTERACTION BETWEEN S100 AND THE RECEPTOR FOR ADVANCED GLYCATION END-PRODUCTS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2009-03-05 | — | — | US | claimed |
| US-20080214491-A1 | Methods of Inhibiting the Interaction Between S100 and the Receptor for Advanced Glycation End-Products | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2008-09-04 | — | — | US | claimed |
| US-8252807-B2 | Methods of inhibiting the interaction between S100 and the receptor for advanced glycation end-products | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2012-08-28 | — | — | US | disclosed |
| US-20110195924-A1 | Methods of Inhibiting the Interaction Between S100P and the Receptor for Advanced Glycation End-Products | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2011-08-11 | — | — | US | disclosed |
| WO-2010042504-A1 | METHODS OF INHIBITING THE INTERACTION BETWEEN S100 AND THE RECEPTOR FOR ADVANCED GLYCATION END-PRODUCTS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2010-04-15 | — | — | WO | disclosed |
| US-20090062319-A1 | METHODS OF INHIBITING THE INTERACTION BETWEEN S100 AND THE RECEPTOR FOR ADVANCED GLYCATION END-PRODUCTS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2009-03-05 | — | — | US | disclosed |
| US-20080214491-A1 | Methods of Inhibiting the Interaction Between S100 and the Receptor for Advanced Glycation End-Products | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2008-09-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214491-A1 | Methods of Inhibiting the Interaction Between S100 and the Receptor for Advanced Glycation End-Products | S100P, S100B, S100A6 | GPR35 164/4885LMNA 648/4885TDP1 3985/4885 |
| US-20090062319-A1 | METHODS OF INHIBITING THE INTERACTION BETWEEN S100 AND THE RECEPTOR FOR ADVANCED GLYCATION END-PRODUCTS | S100P, S100B, S100A6 | GPR35 164/4885LMNA 648/4885TDP1 3985/4885 |
| US-20110195924-A1 | Methods of Inhibiting the Interaction Between S100P and the Receptor for Advanced Glycation End-Products | S100P, S100B, S100A4 | GPR35 206/4885LMNA 628/4885TDP1 3219/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.