Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.63 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 3/20 | 0.41 |
| ▸ | MMP3 | P08254 | 3/20 | 0.41 |
| ▸ | MMP9 | P14780 | 3/20 | 0.41 |
| ▸ | MMP13 | P45452 | 2/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL727047 | 0.87 | BCL2L1 (0.48) | BCL2L1MCL1ALDH1A1LMNAMAPT | |
| SCHEMBL230940 | 0.83 | ALDH1A1 (0.56) | BCL2L1MCL1ALDH1A1LMNAMAPT | |
| SCHEMBL728368 | 0.83 | ALDH1A1 (0.49) | BCL2L1MCL1ALDH1A1LMNAMAPT | |
| SCHEMBL3678664 | 0.74 | ALDH1A1 (0.80) | BCL2L1MCL1ALDH1A1LMNAMAPT | |
| SCHEMBL728360 | 0.73 | KMT2A (0.55) | BCL2L1MCL1ALDH1A1NPSR1POLB | |
| SCHEMBL10917842 | 0.73 | ALDH1A1 (0.61) | BCL2L1MCL1ALDH1A1LMNAMAPT | |
| SCHEMBL728174 | 0.71 | MAPT (0.71) | BCL2L1MCL1ALDH1A1LMNAMAPT | |
| SCHEMBL229080 | 0.71 | ALDH1A1 (0.53) | BCL2L1MCL1ALDH1A1LMNAMAPT | |
| SCHEMBL1565903 | 0.71 | HPGD (0.40) | BCL2L1MCL1ALDH1A1MAPTPOLB | |
| SCHEMBL19642630 | 0.70 | GSK3B (0.61) | ALDH1A1LMNAMAPTHSP90AA1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8329149-B2 | Topical lightening composition and uses thereof | AVON PRODUCTS, INC. (US) | 2012-12-11 | — | — | US | claimed |
| EP-2521558-A1 | TOPICAL LIGHTENING COMPOSITION AND USES THEREOF | Avon Products, Inc. (US) | 2012-11-14 | — | — | EP | claimed |
| US-20120003168-A1 | Topical Lightening Composition and Uses Thereof | AVON PRODUCTS, INC. (US) | 2012-01-05 | — | — | US | claimed |
| WO-2011082044-A1 | TOPICAL LIGHTENING COMPOSITION AND USES THEREOF | AVON PRODUCTS, INC. (US) | 2011-07-07 | — | — | WO | claimed |
| US-8329149-B2 | Topical lightening composition and uses thereof | AVON PRODUCTS, INC. (US) | 2012-12-11 | — | — | US | disclosed |
| US-20120003168-A1 | Topical Lightening Composition and Uses Thereof | AVON PRODUCTS, INC. (US) | 2012-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120003168-A1 | Topical Lightening Composition and Uses Thereof | TYR, AOC3, TH | BCL2L1 4104/4885MCL1 3280/4885ALDH1A1 129/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.