Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2292928 | 0.81 | PKM (0.53) | FGFR1NPC1RAB9AMAPTHPGD | |
| SCHEMBL2298645 | 0.81 | NPC1 (0.56) | NPC1RAB9AMAPTHPGDLMNA | |
| SCHEMBL9231437 | 0.77 | FGFR1 (0.56) | FGFR1NPC1RAB9AMAPTHSD17B10 | |
| SCHEMBL19848676 | 0.74 | MAPT (0.51) | FGFR1NPC1RAB9AMAPTHSD17B10 | |
| SCHEMBL29613720 | 0.74 | MAPT (0.51) | FGFR1NPC1RAB9AMAPTHSD17B10 | |
| SCHEMBL2298534 | 0.73 | EGLN3 (0.45) | NPC1RAB9AMAPTHSD17B10CYP2C19 | |
| SCHEMBL19911416 | 0.68 | MAPT (0.49) | FGFR1MAPTHSD17B10HPGDALDH1A1 | |
| SCHEMBL482648 | 0.68 | NR1H2 (0.43) | FGFR1MAPTHSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL2296957 | 0.67 | HCAR3 (0.50) | FGFR1NPC1RAB9AMAPTHSD17B10 | |
| SCHEMBL2295849 | 0.67 | FGFR1 (0.47) | FGFR1NPC1RAB9AMAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8003806-B2 | Integrin antagonists useful as anticancer agents | OSI Pharmaceuticals, LLC (US) | 2011-08-23 | — | — | US | disclosed |