Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.43 |
| ▸ | PDE2A | O00408 | 7/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | UGCG | Q16739 | 1/20 | 0.39 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.39 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28706200 | 1.00 | GPR139 (0.43) | GPR139GABRB1GABRB2PDE2ACTSS | |
| SCHEMBL28936581 | 0.89 | GABRB1 (0.43) | GPR139GABRB1GABRB2PDE2ACTSS | |
| SCHEMBL29440427 | 0.89 | GPR139 (0.42) | GPR139GABRB1GABRB2PDE2ACTSS | |
| SCHEMBL22952643 | 0.89 | GABRB1 (0.43) | GPR139GABRB1GABRB2PDE2ACTSS | |
| SCHEMBL21272633 | 0.89 | GPR139 (0.42) | GPR139GABRB1GABRB2PDE2ACTSS | |
| SCHEMBL21272631 | 0.89 | GPR139 (0.42) | GPR139GABRB1GABRB2PDE2ACTSS | |
| SCHEMBL29440442 | 0.88 | GPR139 (0.45) | GPR139GABRB1GABRB2PDE2ACTSS | |
| SCHEMBL21272669 | 0.88 | GPR139 (0.45) | GPR139GABRB1GABRB2PDE2ACTSS | |
| SCHEMBL21272671 | 0.88 | GPR139 (0.45) | GPR139GABRB1GABRB2PDE2ACTSS | |
| SCHEMBL22952673 | 0.87 | GPR139 (0.41) | GPR139GABRB1GABRB2PDE2ACTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4461725-A2 | ALCOHOL DERIVATIVES AS KV7 POTASSIUM CHANNEL OPENERS | H. Lundbeck A/S (DK) | 2024-11-13 | — | — | EP | disclosed |
| US-20240327336-A1 | ALCOHOL DERIVATIVES AS KV7 POTASSIUM CHANNEL OPENERS | H. LUNDBECK A/S (DK) | 2024-10-03 | — | — | US | disclosed |
| EP-4007634-B1 | ALCOHOL DERIVATIVES AS KV7 POTASSIUM CHANNEL OPENERS | H LUNDBECK AS (DK) | 2024-10-02 | — | — | EP | disclosed |
| US-11548849-B2 | Alcohol derivatives as KV7 potassium channel openers | H. LUNDBECK A/S (DK) | 2023-01-10 | — | — | US | disclosed |
| US-11548849-B2 | Alcohol derivatives as KV7 potassium channel openers | H. LUNDBECK A/S (DK) | 2023-01-10 | — | — | US | disclosed |
| EP-4007634-A1 | ALCOHOL DERIVATIVES AS KV7 POTASSIUM CHANNEL OPENERS | H. Lundbeck A/S (DK) | 2022-06-08 | — | — | EP | disclosed |
| CN-114206830-A | Alcohol derivatives as Kv7 potassium channel openers | H.隆德贝克有限公司 | 2022-03-18 | — | — | CN | disclosed |
| WO-2021023617-A1 | ALCOHOL DERIVATIVES AS KV7 POTASSIUM CHANNEL OPENERS | H. LUNDBECK A/S (DK) | 2021-02-11 | — | — | WO | disclosed |
| US-20210032196-A1 | ALCOHOL DERIVATIVES AS KV7 POTASSIUM CHANNEL OPENERS | H. LUNDBECK A/S (DK) | 2021-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11548849-B2 | Alcohol derivatives as KV7 potassium channel openers | KCNA7, KCNK17, KCNAB1 | GPR139 592/4885GABRB1 153/4885GABRB2 157/4885 |
| US-20240327336-A1 | ALCOHOL DERIVATIVES AS KV7 POTASSIUM CHANNEL OPENERS | KCNA7, KCNK17, KCNQ1 | GPR139 663/4885GABRB1 169/4885GABRB2 163/4885 |
| US-20210032196-A1 | ALCOHOL DERIVATIVES AS KV7 POTASSIUM CHANNEL OPENERS | KCNA7, KCNK17, KCNQ1 | GPR139 663/4885GABRB1 169/4885GABRB2 163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.