Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.53 |
| ▸ | MAPT | P10636 | 6/20 | 0.53 |
| ▸ | MEN1 | O00255 | 5/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | HTT | P42858 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8985182 | 0.84 | ALDH1A1 (0.42) | KMT2AMAPTMEN1HSD17B10ALOX15 | |
| SCHEMBL28389437 | 0.79 | KMT2A (0.50) | KMT2AMAPTMEN1HSD17B10ALOX15 | |
| SCHEMBL1270467 | 0.78 | MAPT (0.48) | KMT2AMAPTMEN1HSD17B10ALOX15 | |
| SCHEMBL57436 | 0.78 | MEN1 (0.53) | KMT2AMAPTMEN1HSD17B10ALOX15 | |
| SCHEMBL8829718 | 0.77 | TSHR (0.42) | KMT2AMAPTMEN1HSD17B10ALOX15 | |
| SCHEMBL12123166 | 0.74 | MAPT (0.52) | KMT2AMAPTMEN1HSD17B10SMN1; SMN2 | |
| SCHEMBL14128157 | 0.74 | CYP3A4 (0.52) | KMT2AMAPTMEN1HSD17B10ALOX15 | |
| SCHEMBL9492682 | 0.74 | MAPT (0.53) | KMT2AMAPTMEN1HSD17B10ALOX15 | |
| SCHEMBL6586488 | 0.74 | SIGMAR1 (0.40) | IDO1 | |
| SCHEMBL8795345 | 0.74 | MAPT (0.61) | KMT2AMAPTMEN1HSD17B10ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130310433-A1 | THIOPHENE-CARBOXAMIDES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED | 2013-11-21 | — | — | US | disclosed |
| US-8481578-B2 | Thiophene-carboxamides useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-07-09 | — | — | US | disclosed |
| EP-2019826-B1 | THIOPHENE-CARBOXAMIDES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2012-08-29 | — | — | EP | disclosed |
| US-20120165378-A1 | THIOPHENE-CARBOXAMIDES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-06-28 | — | — | US | disclosed |
| US-8039661-B2 | Thiophene-carboxamides useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-10-18 | — | — | US | disclosed |
| US-20110190507-A1 | THIOPHENE-CARBOXAMIDES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-08-04 | — | — | US | disclosed |
| US-7851495-B2 | Thiophene-carboxamides useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-12-14 | — | — | US | disclosed |
| CN-101495474-A | Thiophene-carboxamides useful as inhibitors of protein kinases | VERTEX PHARMA (US) | 2009-07-29 | — | — | CN | disclosed |
| EP-2019826-A1 | THIOPHENE-CARBOXAMIDES USEFUL AS INHIBITORS OF PROTEIN KINASES | Vertex Pharmaceuticals, Inc. (US) | 2009-02-04 | — | — | EP | disclosed |
| US-20080070965-A1 | Thiophene-carboxamides useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED | 2008-03-20 | — | — | US | disclosed |
| WO-2007139795-A1 | THIOPHENE-CARBOXAMIDES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-12-06 | — | — | WO | disclosed |
| US-5266701-A | Process for production of 2-iminothiazolidines and oxazolidines | ICI AMERICAS INC. (US) | 1993-11-30 | — | — | US | disclosed |
| US-4225591-A | CORONARY VASODILATOR | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1980-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130310433-A1 | THIOPHENE-CARBOXAMIDES USEFUL AS INHIBITORS OF PROTEIN KINASES | MAP3K20, MAP3K5, PACSIN2 | KMT2A 886/4885MAPT 1217/4885MEN1 2882/4885 |
| US-20080070965-A1 | Thiophene-carboxamides useful as inhibitors of protein kinases | MAP3K20, MAP3K5, PACSIN2 | KMT2A 886/4885MAPT 1217/4885MEN1 2882/4885 |
| US-20110190507-A1 | THIOPHENE-CARBOXAMIDES USEFUL AS INHIBITORS OF PROTEIN KINASES | MAP3K20, MAP3K5, PACSIN2 | KMT2A 886/4885MAPT 1217/4885MEN1 2882/4885 |
| US-20120165378-A1 | THIOPHENE-CARBOXAMIDES USEFUL AS INHIBITORS OF PROTEIN KINASES | MAP3K20, MAP3K5, PACSIN2 | KMT2A 886/4885MAPT 1217/4885MEN1 2882/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.