Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22954763 | 0.84 | PLA2G4B (0.42) | ALDH1A1GAAL3MBTL1MAPTNPC1 | |
| SCHEMBL22955144 | 0.84 | ALDH1A1 (0.40) | ALDH1A1CYP3A4 | |
| SCHEMBL22954565 | 0.80 | HPGD (0.37) | ALDH1A1GAAMAPTNPC1RAB9A | |
| SCHEMBL22954851 | 0.78 | ALDH1A1 (0.44) | ALDH1A1GAAL3MBTL1MAPTNPC1 | |
| SCHEMBL25819476 | 0.77 | MAPT (0.44) | ALDH1A1GAAL3MBTL1MAPTNPC1 | |
| SCHEMBL25819478 | 0.73 | KMT2A (0.43) | ALDH1A1GAAL3MBTL1MAPTNPC1 | |
| SCHEMBL221788 | 0.73 | MTNR1A (0.53) | ALDH1A1GAAMAPTNPC1RAB9A | |
| SCHEMBL3313592 | 0.72 | PTGS2 (0.53) | ALDH1A1GAAL3MBTL1MAPTNPC1 | |
| SCHEMBL657693 | 0.72 | CHEK1 (0.53) | ALDH1A1GAAL3MBTL1MAPTNPC1 | |
| SCHEMBL22955191 | 0.71 | PDE4A (0.40) | ALDH1A1MAPTSMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021018118-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1 PROTEINS | JANSSEN PHARMACEUTICA NV (BE) | 2021-02-04 | — | — | WO | disclosed |