Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | RECQL | P46063 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CCR3 | P51677 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22955726 | 0.84 | CCR3 (0.47) | PDE4APDE4BPDE4CPDE4DCNR1 | |
| SCHEMBL2825514 | 0.83 | GPR119 (0.53) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL22954702 | 0.81 | TSHR (0.44) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL20632691 | 0.80 | PDE4B (0.49) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL12043181 | 0.80 | PDE4B (0.39) | PDE4BALDH1A1RECQLLMNAMAPT | |
| SCHEMBL12042907 | 0.79 | DRD2 (0.43) | PDE4BALDH1A1RECQLLMNAMAPT | |
| SCHEMBL29446151 | 0.79 | SIRT6 (0.57) | SIRT6ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL375364 | 0.79 | SIRT6 (0.57) | SIRT6ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL12042904 | 0.78 | PDE4B (0.41) | PDE4BALDH1A1RECQLLMNAMAPT | |
| SCHEMBL12042899 | 0.78 | ALDH1A1 (0.45) | SIRT6ALDH1A1RECQLLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021018118-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1 PROTEINS | JANSSEN PHARMACEUTICA NV (BE) | 2021-02-04 | — | — | WO | disclosed |