Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ANPEP | P15144 | 3/20 | 0.37 |
| ▸ | DNPEP | Q9ULA0 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 8/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 8/20 | 0.36 |
| ▸ | KISS1R | Q969F8 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RNPEP | Q9H4A4 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP8 | P22894 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20440215 | 0.89 | ALDH1A1 (0.43) | ALDH1A1ANPEPDNPEPCYP2D6CYP2C19 | |
| SCHEMBL12119814 | 0.87 | CYP2D6 (0.39) | ALDH1A1ANPEPDNPEPCYP2D6CYP2C19 | |
| SCHEMBL10062233 | 0.79 | MTNR1A (0.44) | ALDH1A1CYP2D6CYP2C19MTNR1AMTNR1B | |
| SCHEMBL14953743 | 0.78 | ALDH1A1 (0.39) | ALDH1A1CYP2D6CYP2C19MTNR1AMTNR1B | |
| SCHEMBL8436494 | 0.78 | TSHR (0.42) | CYP2D6CYP2C19MTNR1AMTNR1BKDM4E | |
| SCHEMBL21165837 | 0.77 | CYP2D6 (0.41) | ALDH1A1ANPEPDNPEPCYP2D6CYP2C19 | |
| SCHEMBL22959016 | 0.76 | KDM4E (0.56) | ALDH1A1ANPEPDNPEPMTNR1AMTNR1B | |
| SCHEMBL21750018 | 0.75 | GABRP (0.45) | ANPEPCYP2D6CYP2C19MTNR1AMTNR1B | |
| SCHEMBL14094259 | 0.75 | KDM4E (0.54) | ALDH1A1MTNR1AMTNR1BKISS1RKDM4E | |
| SCHEMBL5092791 | 0.75 | GABRP (0.45) | ANPEPCYP2D6CYP2C19MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210040046-A1 | 2,4-DIAMINOQUINAZOLINE DERIVATIVES AND MEDICAL USES THEREOF | Janssen Sciences Ireland Unlimi (IE) | 2021-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210040046-A1 | 2,4-DIAMINOQUINAZOLINE DERIVATIVES AND MEDICAL USES THEREOF | HRH4, HRH3, HNMT | ALDH1A1 1960/4885ANPEP 1392/4885DNPEP 433/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.