Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.60 |
| ▸ | STIM1 | Q13586 | 2/20 | 0.54 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | BRAF | P15056 | 8/20 | 0.51 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.47 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | CRACR2A | Q9BSW2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30115256 | 1.00 | L3MBTL1 (0.60) | L3MBTL1STIM1ORAI1LMNABRAF | |
| SCHEMBL4768116 | 0.81 | STIM1 (0.61) | L3MBTL1STIM1ORAI1LMNA | |
| SCHEMBL18027793 | 0.79 | STIM1 (0.57) | L3MBTL1STIM1ORAI1LMNATRPC1 | |
| SCHEMBL30728748 | 0.78 | KDM4E (0.64) | L3MBTL1STIM1ORAI1LMNAALDH1A1 | |
| SCHEMBL1329736 | 0.78 | KDM4E (0.64) | L3MBTL1STIM1ORAI1LMNAALDH1A1 | |
| SCHEMBL29579172 | 0.77 | KIF18A (0.61) | L3MBTL1LMNABRAF | |
| SCHEMBL22963043 | 0.77 | KIF18A (0.61) | L3MBTL1LMNABRAF | |
| SCHEMBL12093655 | 0.76 | STIM1 (0.61) | L3MBTL1STIM1ORAI1BRAFTRPC1 | |
| SCHEMBL5027383 | 0.76 | STIM1 (0.60) | L3MBTL1STIM1ORAI1LMNATRPC1 | |
| SCHEMBL16456537 | 0.75 | ORAI1 (0.67) | L3MBTL1STIM1ORAI1LMNABRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021026100-A1 | PYRIDINE DERIVATIVES AS KIF18A INHIBITORS | AMGEN INC. (US) | 2021-02-11 | — | — | WO | disclosed |