Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.60 |
| ▸ | STIM1 | Q13586 | 2/20 | 0.54 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | BRAF | P15056 | 8/20 | 0.51 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.47 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | CRACR2A | Q9BSW2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22963047 | 1.00 | L3MBTL1 (0.60) | L3MBTL1STIM1ORAI1LMNABRAF | |
| SCHEMBL4768116 | 0.81 | STIM1 (0.61) | L3MBTL1STIM1ORAI1LMNA | |
| SCHEMBL18027793 | 0.79 | STIM1 (0.57) | L3MBTL1STIM1ORAI1LMNATRPC1 | |
| SCHEMBL30728748 | 0.78 | KDM4E (0.64) | L3MBTL1STIM1ORAI1LMNAALDH1A1 | |
| SCHEMBL1329736 | 0.78 | KDM4E (0.64) | L3MBTL1STIM1ORAI1LMNAALDH1A1 | |
| SCHEMBL29579172 | 0.77 | KIF18A (0.61) | L3MBTL1LMNABRAF | |
| SCHEMBL22963043 | 0.77 | KIF18A (0.61) | L3MBTL1LMNABRAF | |
| SCHEMBL12093655 | 0.76 | STIM1 (0.61) | L3MBTL1STIM1ORAI1BRAFTRPC1 | |
| SCHEMBL5027383 | 0.76 | STIM1 (0.60) | L3MBTL1STIM1ORAI1LMNATRPC1 | |
| SCHEMBL16456537 | 0.75 | ORAI1 (0.67) | L3MBTL1STIM1ORAI1LMNABRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12540129-B2 | KIF18A inhibitors | AMGEN INC. (US) | 2026-02-03 | — | — | US | disclosed |
| US-20220372018-A1 | KIF18A INHIBITORS | AMGEN INC. (US) | 2022-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12540129-B2 | KIF18A inhibitors | KIF18A, KIFC1, KIF2C | L3MBTL1 2632/4885STIM1 3658/4885ORAI1 4222/4885 |
| US-20220372018-A1 | KIF18A INHIBITORS | KIF18A, KIF18B, KIF15 | L3MBTL1 3474/4885STIM1 3582/4885ORAI1 4436/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.