Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | FBP1 | P09467 | 3/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31292359 | 0.88 | CNR2 (0.45) | MAPTFBP1MMP8TSHRALDH1A1 | |
| SCHEMBL25341772 | 0.85 | ACSS2 (0.43) | MAPTFBP1TSHRKDM4ELMNA | |
| SCHEMBL30636540 | 0.83 | TSHR (0.35) | MAPTFBP1MMP8TSHRALDH1A1 | |
| SCHEMBL20972033 | 0.83 | TSHR (0.35) | MAPTFBP1MMP8TSHRALDH1A1 | |
| SCHEMBL30853648 | 0.82 | TSHR (0.36) | MAPTFBP1TSHRALDH1A1CYP1A2 | |
| SCHEMBL23070510 | 0.82 | MMP8 (0.37) | FBP1MMP8TSHRCYP1A2ABCB11 | |
| SCHEMBL140210 | 0.82 | TSHR (0.36) | MAPTFBP1TSHRALDH1A1CYP1A2 | |
| SCHEMBL11730443 | 0.79 | ALDH1A1 (0.41) | MAPTMMP8ALDH1A1KDM4ELMNA | |
| SCHEMBL2139064 | 0.79 | KDM4E (0.40) | MAPTCYP1A2KDM4ELMNAMAPK1 | |
| SCHEMBL142930 | 0.78 | THRB (0.44) | MAPTFBP1ALDH1A1CYP1A2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114302880-A | KIF18A inhibitors | 美国安进公司 | 2022-04-08 | — | — | CN | disclosed |
| WO-2021026098-A1 | KIF18A INHIBITORS | AMGEN INC. (US) | 2021-02-11 | — | — | WO | disclosed |