Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AMY1A | P0DUB6 | 2/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | PLAU | P00749 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1156230 | 0.79 | HTT (0.46) | EGLN1NOS1DYRK1AHTT | |
| SCHEMBL13604198 | 0.79 | PRNP (0.36) | GRM2NOS1DYRK1AHTT | |
| SCHEMBL5440650 | 0.76 | GRM2 (0.34) | GRM2EGLN1 | |
| SCHEMBL14468054 | 0.76 | HTT (0.39) | AMY1AEGLN1HTT | |
| SCHEMBL166351 | 0.76 | ALDH1A1 (0.35) | HTT | |
| SCHEMBL3392523 | 0.76 | POLB (0.34) | HTT | |
| Water SCHEMBL2477029 | 0.74 | ALDH1A1 (0.34) | HTT | |
| SCHEMBL29285947 | 0.72 | MEN1 (0.42) | HTT | |
| SCHEMBL3394106 | 0.72 | RIPK1 (0.43) | GRM2EGLN1 | |
| SCHEMBL14445626 | 0.72 | GABRA1 (0.42) | HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021026375-A1 | FUSED BICYCLIC COMPOUNDS FOR THE TREATMENT OF PAIN | ALKERMES, INC. (US) | 2021-02-11 | — | — | WO | disclosed |
| WO-2021026375-A1 | FUSED BICYCLIC COMPOUNDS FOR THE TREATMENT OF PAIN | ALKERMES, INC. (US) | 2021-02-11 | — | — | WO | disclosed |