Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | TP53 | P04637 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18095501 | 0.89 | CYP2C9 (0.44) | PTGS2MEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL2295394 | 0.88 | ALOX5 (0.52) | PTGS2MEN1KMT2AMAPTTP53 | |
| SCHEMBL6120029 | 0.88 | MAPT (0.43) | PTGS2MEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL9952934 | 0.87 | CYP2C9 (0.46) | PTGS2MEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL15455978 | 0.87 | MAPT (0.42) | PTGS2MEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL2297048 | 0.83 | PTGS2 (0.53) | PTGS2MEN1KMT2AMAPTKDM4E | |
| SCHEMBL6119862 | 0.82 | MAPT (0.43) | PTGS2MEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL2297094 | 0.81 | CYP2C9 (0.53) | PTGS2MEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL6119409 | 0.81 | MAPT (0.42) | PTGS2MEN1KMT2AMAPTTP53 | |
| SCHEMBL14697648 | 0.81 | ALOX5 (0.45) | MEN1KMT2ACYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012067663-A1 | COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-05-24 | — | — | WO | disclosed |
| WO-2011103063-A1 | THERAPEUTIC COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2011-08-25 | — | — | WO | disclosed |