Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.42 |
| ▸ | TP53 | P04637 | 5/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | PRNP | P04156 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18095501 | 0.91 | CYP2C9 (0.44) | MAPTTP53POLBTHRBSMN1; SMN2 | |
| SCHEMBL6118798 | 0.83 | ALOX5 (0.46) | MAPTALOX5MEN1KMT2APRNP | |
| SCHEMBL9952934 | 0.82 | CYP2C9 (0.46) | MAPTTP53POLBTHRBSMN1; SMN2 | |
| SCHEMBL2295394 | 0.82 | ALOX5 (0.52) | MAPTTP53POLBTHRBSMN1; SMN2 | |
| SCHEMBL2297091 | 0.81 | PTGS2 (0.45) | MAPTTP53POLBTHRBSMN1; SMN2 | |
| SCHEMBL6119280 | 0.80 | TRPV1 (0.40) | — | |
| SCHEMBL15455978 | 0.79 | MAPT (0.42) | MAPTTP53POLBTHRBSMN1; SMN2 | |
| SCHEMBL6120029 | 0.79 | MAPT (0.43) | MAPTTP53POLBTHRBSMN1; SMN2 | |
| SCHEMBL6118842 | 0.78 | ALOX5 (0.43) | MAPTTP53THRBSMN1; SMN2ALOX5 | |
| SCHEMBL6119825 | 0.78 | CYP2C9 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012067663-A1 | COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-05-24 | — | — | WO | disclosed |