Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.43 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.43 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10305437 | 0.92 | KMT2A (0.44) | KMT2ALMNAPDE10APTGER4CCNB2 | |
| SCHEMBL3559690 | 0.91 | TSHR (0.46) | PTGER4CNR1CNR2CYP2C19CYP1A2 | |
| SCHEMBL1590385 | 0.91 | ALDH1A1 (0.47) | KMT2ALMNAPTGER4ALDH1A1KDM4E | |
| SCHEMBL3560912 | 0.89 | ADORA3 (0.45) | KMT2ALMNAALDH1A1KDM4EHPGD | |
| SCHEMBL3571297 | 0.89 | KMT2A (0.39) | KMT2ALMNAPDE10APTGER4CCNB2 | |
| SCHEMBL3564124 | 0.88 | TSHR (0.51) | KMT2ALMNAALDH1A1MEN1MAPT | |
| SCHEMBL10305436 | 0.87 | AGTR1 (0.41) | KMT2APTGER4ALDH1A1KDM4EHPGD | |
| SCHEMBL2299912 | 0.85 | PTGER4 (0.47) | KMT2ALMNAPTGER4ALDH1A1KDM4E | |
| SCHEMBL2300382 | 0.84 | PTGER4 (0.46) | KMT2ALMNAPTGER4ALDH1A1KDM4E | |
| SCHEMBL2300372 | 0.84 | PTGER4 (0.46) | KMT2ALMNAPTGER4ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1886993-B1 | BENZO[F]ISOINDOLE DERIVATIVES WITH AFFINITY TO THE EP4 RECEPTOR | GLAXO GROUP LTD (GB) | 2013-09-18 | — | — | EP | disclosed |
| US-8252833-B2 | Benzo (f) isoindol-2-ylphenyl acetic acid derivatives as EP4 receptor agonists | GLAXO GROUP LIMITED (GB) | 2012-08-28 | — | — | US | disclosed |
| US-8252833-B2 | Benzo (f) isoindol-2-ylphenyl acetic acid derivatives as EP4 receptor agonists | GLAXO GROUP LIMITED (GB) | 2012-08-28 | — | — | US | disclosed |
| US-8252833-B2 | Benzo (f) isoindol-2-ylphenyl acetic acid derivatives as EP4 receptor agonists | GLAXO GROUP LIMITED (GB) | 2012-08-28 | — | — | US | disclosed |
| EP-1979316-B1 | BENZO (F) ISOINDOL-2-YLPHENYL ACETIC ACID DERIVATIVES AS EP4 RECEPTOR AGONISTS | GLAXO GROUP LTD (GB) | 2012-07-11 | — | — | EP | disclosed |
| EP-2457897-A1 | BENZO (F) ISOINDOL-2-YLPHENYL ACETIC ACID DERIVATIVES AS EP4 RECEPTOR AGONISTS | Glaxo Group Limited (GB) | 2012-05-30 | — | — | EP | disclosed |
| US-20110201663-A1 | BENZO (F) ISOINDOL-2-YLPHENYL ACETIC ACID DERIVATIVES AS EP4 RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 2011-08-18 | — | — | US | disclosed |
| US-20110201663-A1 | BENZO (F) ISOINDOL-2-YLPHENYL ACETIC ACID DERIVATIVES AS EP4 RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 2011-08-18 | — | — | US | disclosed |
| US-20110201663-A1 | BENZO (F) ISOINDOL-2-YLPHENYL ACETIC ACID DERIVATIVES AS EP4 RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 2011-08-18 | — | — | US | disclosed |
| EP-2081897-B1 | ISOINDOL DERIVATIVES AS EP4 RECEPTOR AGONISTS | GLAXO GROUP LTD (GB) | 2010-09-15 | — | — | EP | disclosed |
| WO-2008061955-A1 | BENZOISOINDOLE DERIVATIVES AND THEIR USE AS EP4 RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 2008-05-29 | — | — | WO | disclosed |
| WO-2008046798-A1 | ISOINDOL DERIVATIVES AS EP4 RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 2008-04-24 | — | — | WO | disclosed |
| EP-1886993-A1 | BENZO[F]ISOINDOLE DERIVATIVES WITH AFFINITY TO THE EP4 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2008-02-13 | — | — | EP | disclosed |
| WO-2007088190-A1 | BENZO (F) ISOINDOL-2-YLPHENYL ACETIC ACID DERIVATIVES AS EP4 RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 2007-08-09 | — | — | WO | disclosed |
| EP-1368312-B1 | BENZO[F]ISOINDOLE DERIVATIVES WITH AFFINITY TO THE EP4 RECEPTOR | GLAXO GROUP LTD (GB) | 2007-06-27 | — | — | EP | disclosed |
| US-20070088068-A1 | Benzo[F]Isoindole Derivatives With Affinity To The EP4 Receptor | CONGREVE MILES S | 2007-04-19 | — | — | US | disclosed |
| US-7166631-B2 | Benzo[f]isoindole derivatives with affinity to the EP4 receptor | GLAXO GROUP LIMITED (GB) | 2007-01-23 | — | — | US | disclosed |
| US-20050080257-A1 | Benzo'fisoindole derivatives with affinity to the ep4 receptor | GLAXO GROUP LIMITED (GB) | 2005-04-14 | — | — | US | disclosed |
| EP-1368312-A1 | BENZO'F!ISOINDOLE DERIVATIVES WITH AFFINITY TO THE EP4 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2003-12-10 | — | — | EP | disclosed |
| WO-2002064564-A1 | BENZO'F!ISOINDOLE DERIVATIVES WITH AFFINITY TO THE EP4 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2002-08-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110201663-A1 | BENZO (F) ISOINDOL-2-YLPHENYL ACETIC ACID DERIVATIVES AS EP4 RECEPTOR AGONISTS | PTGER4, PTGER1, PTGER2 | KMT2A 3572/4885LMNA 2979/4885PDE10A 858/4885 |
| US-20050080257-A1 | Benzo'fisoindole derivatives with affinity to the ep4 receptor | PTGER4, PTGER1, PTGER3 | KMT2A 3630/4885LMNA 2601/4885PDE10A 2809/4885 |
| US-20070088068-A1 | Benzo[F]Isoindole Derivatives With Affinity To The EP4 Receptor | PTGER4, PTGER1, GPR4 | KMT2A 3569/4885LMNA 2990/4885PDE10A 2230/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.