Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS2 | Q9H2K2 | 7/20 | 0.61 |
| ▸ | GUSB | P08236 | 6/20 | 0.61 |
| ▸ | TNKS | O95271 | 5/20 | 0.61 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.61 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.61 |
| ▸ | PARP1 | P09874 | 4/20 | 0.61 |
| ▸ | QTRT1 | Q9BXR0 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.49 |
| ▸ | TUBB | P07437 | 1/20 | 0.49 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.49 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.49 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.49 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.49 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30852300 | 1.00 | TNKS2 (0.61) | TNKS2GUSBTNKSPARP2NLRP3 | |
| SCHEMBL15775356 | 0.77 | TNKS (1.00) | TNKS2GUSBTNKSPARP2NLRP3 | |
| SCHEMBL12591965 | 0.77 | GUSB (1.00) | TNKS2GUSBTNKSPARP2NLRP3 | |
| SCHEMBL26017627 | 0.76 | TNKS2 (0.61) | TNKS2GUSBTNKSPARP2PARP1 | |
| SCHEMBL31251212 | 0.76 | MMP2 (0.58) | NPC1RAB9APKMKMT2AALDH1A1 | |
| SCHEMBL186382 | 0.76 | MMP2 (0.58) | NPC1RAB9APKMKMT2AALDH1A1 | |
| SCHEMBL31070302 | 0.76 | TNKS2 (0.61) | TNKS2GUSBTNKSPARP2PARP1 | |
| SCHEMBL47352 | 0.76 | PARP1 (1.00) | TNKS2TNKSPARP1QTRT1NPC1 | |
| SCHEMBL6695759 | 0.75 | TNKS2 (0.81) | TNKS2GUSBTNKSPARP2PARP1 | |
| SCHEMBL9483143 | 0.74 | MMP2 (0.57) | NPC1RAB9APKMKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105377831-B | Synthesis of 3- (5-amino-2-methyl-4-oxoquinazolin-3 (4H) -yl) piperidine-2, 6-dione | 细胞基因公司 | 2018-02-02 | — | — | CN | claimed |
| CN-115340541-B | Preparation method of tocartinib intermediate | 上海艾洋化学科技有限公司 | 2024-01-30 | — | — | CN | disclosed |
| US-11524956-B2 | Alkyne substituted quinazoline compound and methods of use | NEWGEN THERAPEUTICS, INC. (US) | 2022-12-13 | — | — | US | disclosed |
| US-20210047303-A1 | ALKYNE SUBSTITUTED QUINAZOLINE COMPOUND AND METHODS OF USE | KANION USA INC. | 2021-02-18 | — | — | US | disclosed |
| CN-105377831-B | Synthesis of 3- (5-amino-2-methyl-4-oxoquinazolin-3 (4H) -yl) piperidine-2, 6-dione | 细胞基因公司 | 2018-02-02 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11524956-B2 | Alkyne substituted quinazoline compound and methods of use | ERBB2, ERBB4, ERBB3 | TNKS2 559/4885GUSB 4213/4885TNKS 653/4885 |
| US-20210047303-A1 | ALKYNE SUBSTITUTED QUINAZOLINE COMPOUND AND METHODS OF USE | ERBB2, ERBB4, ERBB3 | TNKS2 559/4885GUSB 4213/4885TNKS 653/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.