Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 2/20 | 0.35 |
| ▸ | PARP1 | P09874 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.33 |
| ▸ | MPO | P05164 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CD38 | P28907 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.32 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | PLK1 | P53350 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16735683 | 0.71 | HDAC3 (0.52) | MEN1KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL30634304 | 0.69 | PLA2G10 (0.50) | CHEK2MEN1KMT2APLA2G10PLA2G2A | |
| SCHEMBL1890156 | 0.65 | DRD4 (0.51) | MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL8992820 | 0.64 | ESR1 (0.59) | KDM4EALDH1A1NPC1RAB9APOLB | |
| SCHEMBL6080013 | 0.63 | CYP1A2 (0.46) | MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL3946630 | 0.62 | ADORA2A (0.45) | PARP1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL29053731 | 0.62 | ALDH1A1 (0.36) | MEN1KMT2AKDM4EALDH1A1HTT | |
| SCHEMBL6079724 | 0.61 | CYP1A2 (0.47) | KMT2AKDM4EALDH1A1PLA2G2A | |
| SCHEMBL27969275 | 0.61 | KIF11 (0.55) | MEN1KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL28613561 | 0.60 | PLA2G10 (0.46) | MEN1KMT2APLA2G10PLA2G2ACCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519505-A1 | NEW TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | Polichem SA (LU) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011080264-A1 | NEW TERTIARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES AND USES THEREOF | POLICHEM S.A. (LU) | 2011-07-07 | — | — | WO | disclosed |