Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.45 |
| ▸ | RAB9A | P51151 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | RARA | P10276 | 1/20 | 0.43 |
| ▸ | RARB | P10826 | 1/20 | 0.43 |
| ▸ | RARG | P13631 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22978663 | 1.00 | NPC1 (0.45) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL29446210 | 1.00 | NPC1 (0.45) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL29653966 | 1.00 | NPC1 (0.45) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL28332237 | 0.89 | MAP3K14 (0.54) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL4336968 | 0.89 | MAP3K14 (0.54) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL4336961 | 0.89 | MAP3K14 (0.54) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL25671220 | 0.86 | ALDH1A1 (0.44) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL19647790 | 0.85 | NPC1 (0.47) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL30405829 | 0.84 | ALDH1A1 (0.43) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL803156 | 0.84 | ALDH1A1 (0.43) | NPC1RAB9AMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250066379-A1 | ANTIMALARIAL AGENTS | MERCK SHARP & DOHME LLC (US) | 2025-02-27 | — | — | US | disclosed |
| CN-118922422-A | Antimalarial drugs | 默沙东有限责任公司 | 2024-11-08 | — | — | CN | disclosed |
| EP-4444722-A1 | ANTIMALARIAL AGENTS | Merck Sharp & Dohme LLC (US) | 2024-10-16 | — | — | EP | disclosed |
| US-20230355622-A1 | METHODS OF CHEMOVACCINATION AGAINST PLASMODIUM INFECTIONS | MERCK SHARP & DOHME LLC (US) | 2023-11-09 | — | — | US | disclosed |
| US-20230355622-A1 | METHODS OF CHEMOVACCINATION AGAINST PLASMODIUM INFECTIONS | MERCK SHARP & DOHME LLC (US) | 2023-11-09 | — | — | US | disclosed |
| US-20230355622-A1 | METHODS OF CHEMOVACCINATION AGAINST PLASMODIUM INFECTIONS | MERCK SHARP & DOHME LLC (US) | 2023-11-09 | — | — | US | disclosed |
| EP-4216957-A1 | METHODS OF CHEMOVACCINATION AGAINST PLASMODIUM INFECTIONS | Merck Sharp & Dohme LLC (US) | 2023-08-02 | — | — | EP | disclosed |
| WO-2023107356-A1 | ANTIMALARIAL AGENTS | MERCK SHARP & DOHME LLC (US) | 2023-06-15 | — | — | WO | disclosed |
| WO-2023107356-A1 | ANTIMALARIAL AGENTS | MERCK SHARP & DOHME LLC (US) | 2023-06-15 | — | — | WO | disclosed |
| WO-2023102747-A1 | ANTIMALARIAL AGENTS | MERCK SHARP & DOHME LLC (US) | 2023-06-15 | — | — | WO | disclosed |
| WO-2023102747-A1 | ANTIMALARIAL AGENTS | MERCK SHARP & DOHME LLC (US) | 2023-06-15 | — | — | WO | disclosed |
| US-20220331321-A1 | ANTIMALARIAL AGENTS | MERCK SHARP & DOHME CORP. (US) | 2022-10-20 | — | — | US | disclosed |
| EP-4013742-A1 | ANTIMALARIAL AGENTS | Merck Sharp & Dohme Corp. (US) | 2022-06-22 | — | — | EP | disclosed |
| WO-2022066545-A1 | METHODS OF CHEMOVACCINATION AGAINST PLASMODIUM INFECTIONS | MERCK SHARP & DOHME CORP. (US) | 2022-03-31 | — | — | WO | disclosed |
| WO-2021026884-A1 | ANTIMALARIAL AGENTS | MERCK SHARP & DOHME CORP. (US) | 2021-02-18 | — | — | WO | disclosed |
| WO-2021027502-A1 | ANTIMALARIAL AGENTS | MERCK SHARP & DOHME CORP. (US) | 2021-02-18 | — | — | WO | disclosed |
| WO-2021026884-A1 | ANTIMALARIAL AGENTS | MERCK SHARP & DOHME CORP. (US) | 2021-02-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230355622-A1 | METHODS OF CHEMOVACCINATION AGAINST PLASMODIUM INFECTIONS | CTSL, PRCP, CPB1 | NPC1 1843/4885RAB9A 733/4885MEN1 3828/4885 |
| US-20220331321-A1 | ANTIMALARIAL AGENTS | CTSL, SERPINA3, SERPINB1 | NPC1 887/4885RAB9A 1433/4885MEN1 2365/4885 |
| US-20250066379-A1 | ANTIMALARIAL AGENTS | CTSL, PEPD, SERPINB1 | NPC1 1011/4885RAB9A 1804/4885MEN1 2500/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.