Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 13/20 | 0.37 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.36 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 2/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.36 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.35 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.35 |
| ▸ | ITGAL | P20701 | 2/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22982032 | 0.89 | ERCC1 (0.36) | PNMTERCC1ERCC4ESR1ESR2 | |
| SCHEMBL29391234 | 0.81 | ESR2 (0.56) | ESR2ACACB | |
| SCHEMBL22993605 | 0.81 | ESR2 (0.56) | ESR2ACACB | |
| SCHEMBL22981526 | 0.81 | DRD2 (0.47) | ERCC1ERCC4ESR1ESR2ITGB2 | |
| SCHEMBL22982373 | 0.76 | PNMT (0.36) | PNMTERCC1ERCC4ESR1ESR2 | |
| SCHEMBL22981751 | 0.73 | BTK (0.34) | ERCC1ERCC4ESR1ESR2ITGB2 | |
| SCHEMBL28208680 | 0.73 | NOTUM (0.35) | ALDH1A1HPGDHTT | |
| SCHEMBL29097985 | 0.72 | DRD2 (0.48) | PNMTESR1ESR2 | |
| SCHEMBL17607348 | 0.71 | RAC1 (0.38) | ESR1ESR2 | |
| SCHEMBL22981196 | 0.71 | ESR1 (0.43) | ESR1ESR2ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4010333-A1 | PLASMA KALLIKREIN INHIBITORS | Kalvista Pharmaceuticals Limited (GB) | 2022-06-15 | — | — | EP | disclosed |
| WO-2021028645-A1 | PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2021-02-18 | — | — | WO | disclosed |
| WO-2021028649-A1 | PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2021-02-18 | — | — | WO | disclosed |