Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC1 | P07992 | 1/20 | 0.36 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 4/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.35 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.35 |
| ▸ | ITGAL | P20701 | 2/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | PNMT | P11086 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ABHD6 | Q9BV23 | 2/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22982829 | 0.89 | PNMT (0.37) | ERCC1ERCC4ESR1ESR2ITGB2 | |
| SCHEMBL29390616 | 0.81 | ESR2 (0.56) | ESR2KMT2AACACB | |
| SCHEMBL22993328 | 0.81 | ESR2 (0.56) | ESR2KMT2AACACB | |
| SCHEMBL22981526 | 0.81 | DRD2 (0.47) | ERCC1ERCC4ESR1ESR2KMT2A | |
| SCHEMBL18584701 | 0.79 | ABHD6 (0.43) | KMT2AALDH1A1HPGDABHD6HDAC8 | |
| SCHEMBL28931068 | 0.76 | TAAR1 (0.36) | ESR1ESR2KMT2AACACBALDH1A1 | |
| SCHEMBL22981745 | 0.74 | NPC1 (0.35) | ESR1ESR2KMT2ATDP1ALDH1A1 | |
| SCHEMBL28208680 | 0.73 | NOTUM (0.35) | KMT2AALDH1A1HPGDHTTABHD6 | |
| SCHEMBL22981727 | 0.71 | NPC1 (0.35) | KMT2AALDH1A1HPGDABHD6SMN1; SMN2 | |
| SCHEMBL17607348 | 0.71 | RAC1 (0.38) | ESR1ESR2KMT2AABHD6SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4010333-A1 | PLASMA KALLIKREIN INHIBITORS | Kalvista Pharmaceuticals Limited (GB) | 2022-06-15 | — | — | EP | disclosed |
| WO-2021028645-A1 | PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2021-02-18 | — | — | WO | disclosed |
| WO-2021028649-A1 | PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2021-02-18 | — | — | WO | disclosed |