Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 14/20 | 0.36 |
| ▸ | ESR1 | P03372 | 2/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.34 |
| ▸ | HTR5A | P47898 | 1/20 | 0.33 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.33 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22981745 | 0.87 | NPC1 (0.35) | ESR1ESR2HTR5APTGDR2ABHD6 | |
| SCHEMBL22993222 | 0.81 | ESR2 (0.52) | ESR2ABHD6 | |
| SCHEMBL29697629 | 0.81 | ESR2 (0.52) | ESR2ABHD6 | |
| SCHEMBL29388817 | 0.81 | ESR2 (0.52) | ESR2ABHD6 | |
| SCHEMBL22982829 | 0.76 | PNMT (0.37) | PNMTESR1ESR2ERCC1ERCC4 | |
| SCHEMBL29097985 | 0.74 | DRD2 (0.48) | PNMTESR1ESR2 | |
| SCHEMBL22981196 | 0.72 | ESR1 (0.43) | ESR1ESR2 | |
| SCHEMBL22981751 | 0.72 | BTK (0.34) | ESR1ESR2HTR5AERCC1ERCC4 | |
| SCHEMBL13082467 | 0.72 | RIPK1 (0.49) | HTR5APTGDR2ABHD6 | |
| SCHEMBL16147790 | 0.70 | TMEM97 (0.41) | HTR5APTGDR2ABHD6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4010333-A1 | PLASMA KALLIKREIN INHIBITORS | Kalvista Pharmaceuticals Limited (GB) | 2022-06-15 | — | — | EP | disclosed |
| WO-2021028645-A1 | PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2021-02-18 | — | — | WO | disclosed |
| WO-2021028649-A1 | PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2021-02-18 | — | — | WO | disclosed |