Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.64 |
| ▸ | RAB9A | P51151 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | MAOB | P27338 | 1/20 | 0.58 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.57 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6325847 | 0.91 | MAPT (0.64) | MAPTRAB9AL3MBTL1NPC1KDM4E | |
| SCHEMBL6319805 | 0.87 | MAPT (0.68) | MAPTRAB9AALDH1A1L3MBTL1NPC1 | |
| SCHEMBL6321338 | 0.87 | MAPT (0.64) | MAPTRAB9AALDH1A1L3MBTL1NPC1 | |
| SCHEMBL6318934 | 0.87 | MAPT (0.78) | MAPTRAB9AL3MBTL1NPC1KDM4E | |
| SCHEMBL6328277 | 0.87 | MAPT (0.64) | MAPTRAB9AALDH1A1L3MBTL1NPC1 | |
| SCHEMBL3868073 | 0.85 | MAPT (0.63) | MAPTRAB9AL3MBTL1NPC1KDM4E | |
| SCHEMBL3866097 | 0.84 | MAPT (0.57) | MAPTRAB9AALDH1A1L3MBTL1NPC1 | |
| SCHEMBL6204121 | 0.83 | LMNA (0.64) | MAPTRAB9AL3MBTL1NPC1KDM4E | |
| SCHEMBL6326562 | 0.83 | LMNA (0.64) | MAPTRAB9AL3MBTL1NPC1KDM4E | |
| SCHEMBL29446640 | 0.83 | MAPT (0.69) | MAPTRAB9AALDH1A1L3MBTL1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272036-A1 | Ketones | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | US | claimed |
| EP-1549600-A1 | KETONES | AstraZeneca AB (SE) | 2005-07-06 | — | — | EP | claimed |
| WO-2004011410-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-05 | — | — | WO | claimed |