Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KCNA5 | P22460 | 6/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | KCNE1 | P15382 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | SCN1A | P35498 | 1/20 | 0.34 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.34 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.34 |
| ▸ | CCR7 | P32248 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24984061 | 0.77 | SCN8A (0.42) | TSHRNPC1RAB9AKCNA5KCNH2 | |
| SCHEMBL11319209 | 0.76 | CXCR4 (0.41) | TSHRKCNA5KCNH2SLC6A2SLC6A4 | |
| SCHEMBL19308899 | 0.76 | TSHR (0.38) | TSHRKCNA5KCNH2SLC6A2SLC6A4 | |
| SCHEMBL8092360 | 0.73 | SLC6A2 (0.47) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8252287 | 0.73 | GABRA1 (0.54) | CXCR2 | |
| SCHEMBL3249970 | 0.72 | MAOA (0.50) | TSHRSMN1; SMN2KCNA5KCNH2SLC6A2 | |
| SCHEMBL24845424 | 0.71 | TSHR (0.48) | TSHRSMN1; SMN2KCNA5KCNH2SLC6A2 | |
| SCHEMBL11327252 | 0.70 | KDM4E (0.39) | TSHRSMN1; SMN2KCNA5KCNH2SLC6A3 | |
| SCHEMBL27565475 | 0.70 | GABRA1 (0.41) | CXCR2CCR7ALDH1A1LMNA | |
| SCHEMBL10247782 | 0.69 | KCNA5 (0.52) | TSHRSMN1; SMN2KCNA5KCNH2SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10918622-B2 | Compounds useful as kinase inhibitors | LOXO ONCOLOGY, INC. (US) | 2021-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10918622-B2 | Compounds useful as kinase inhibitors | BTK, ABL1, LCK | TSHR 3509/4885NPC1 3295/4885RAB9A 2532/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.